This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
The Financial Settlement in the Enlargement of the European Union: Lessons for Romania? [PDF]
At the end of every European Union accession negotiation, there is a fight about finance. Yet finance is by no means the most important element of the negotiations.
Alan Mayhew
doaj
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Six Years in Managing Structural Funds in Romania. Lessons Learned
The absorption of structural and cohesion funds is one of Romania’s top priorities. Nevertheless, with a very weak absorption rate (11.47% as of December 31st 2012, according to official data), the overall situation is particularly alarming, considering
Dragoş JALIU, Crina RĂDULESCU
doaj +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
The European Cohesion Policy and Structural Funds in Sparsely Populated Areas: A Case Study of the University of Oulu [PDF]
The regional policy is one of the European Union’s main investment policies to support regional equality and convergence, cohesion policy being one of its key policy areas and aiming to support job creation, business competitiveness, economic growth ...
Eija-Riita Niinikoski +2 more
doaj
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Unveiling the impact of European Structural Funds for innovation in Andalusia, Spain
This study evaluates the impact of European Union Structural Funds for innovation on key business indicators related to growth, profitability, and innovation at the regional level.
Diego Sande Veiga
doaj +1 more source
STUDY REGARDING THE IMPLEMENTED PROJECTS BY THE MEMBERS OF THE TERRITORIAL PACT CENTRE AND THE IDENTIFICATION OF PROJECT IDEAS [PDF]
The study was conducted within the project „The establishment of the Permanent Technical Secretariat of the Territorial Pact Centre for Employment and Social Inclusion in the Centre Region”, a project co-financed by the European Social Fund through the ...
ALINA-TEODORA CIUHUREANU +2 more
doaj

