Results 101 to 110 of about 9,782,476 (251)
BuildingsPrevious studies of road or railway infrastructures have shown that traffic emissions outweigh the environmental impacts of the product stage and construction stage over the entire life cycle.
Lukas Hausberger +2 more
doaj +1 more source
Isogeometric finite element-based simulation of the aortic heart valve: Integration of neural network structural material model and structural tensor fiber architecture representations. [PDF]
Int J Numer Method Biomed Eng, 2021 Zhang W +4 more
europepmc +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Structural and functional studies on Nod Like Receptors: insights into NAIP/NLRC4 inflammasome formation [PDF]
, 2013 Our immune system is under constant attack of invading pathogens. The initiation of an appropriate immune response that leads to clearance of these microorganisms and infected cells is dependent on the ability of the immune system to discern between ...
Sub Crystal and Structural Chemistry +2 more
core
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Embedment tests perpendicular to the grain – optical measurements of deformation fields
, 2011 This paper reveals additional knowledge on the bearing behaviour of single fastener connections. By means of non-contact full-field deformation measurements the deformation fields were recorded for different test configurations.
Schoenmakers, J.C.M., Svensson, S.
core +1 more source
InfrastructuresThis review paper investigates the current state of research on structure-to-human interaction (S2HI) in the monitoring and control of cyclo-pedestrian footbridges, focusing specifically on the biodynamic effects of oscillations on pedestrians.
Aurora Caloni +3 more
doaj +1 more source