Results 111 to 120 of about 9,782,476 (251)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Nothing is lost, nothing is created, everything is reused: structural design for a circular economy [PDF]
Structural designers’ efforts to reduce environmental impacts traditionally consist of developing systems that minimise material quantities or use low-impact materials.
Brütting, Jan, Fivet, Corentin
core +1 more source
Construction Material for Tribo-Fatigue Systems: Fatigue Resistance and Structure
Механика машин, механизмов и материалов, 2018 A brief overview of the practical use of the new construction material of MONICA is given. An experimental study was performed for the first time on the analysis of the influence of the microstructural state on fatigue resistance.
Leonid A. Sosnovskiy +5 more
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Analytical model of a composite girder with flexible adhesive bondline
Archives of MechanicsThe paper presents a linear elastic one-dimensional Discrete Layer–Wise (DLW) analytical model of a composite girder consisting of two beams bonded together with a layer of a flexible adhesive.
P. Szeptyński
doaj +1 more source
An all-natural bioinspired structural material for plastic replacement. [PDF]
Nat Commun, 2020 Guan QF +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Compressive capacity perpendicular to grain of fully supported timber beams of Poplar - model comparison [PDF]
, 2015 In timber frame structures, for both residential and multi-storey purposes, timber elements are loaded perpendicular to grain. In the past, structural design code calculations were based on pre-set permissible strength values, applying empirical models ...
Leijten, A.J.M., Haddad, Y.M.
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source