Results 71 to 80 of about 9,782,476 (251)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Acetylated wood in structural applications

, 2010
Since the commercial introduction of acetylated wood on the market by Titan Wood in 2007, Accoya® wood has been applied in many different ways. In general, wood modification opens a whole new and broad range of innovative or renewed applications for ...
Jorissen, A.J.M., Hill, C., Blass, H.J., Bongers, F., Alexander, J.   +4 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Structural Applications in Aluminium: an Overview

, 2007
This paper deals with structural applications of aluminium. First, design and calculation is introduced. The problems the designer is faced with are described or in other words how to arrive at an optimum design in aluminium.
Soetens, F., Soetens, F Frans
core  

Perpendicular to grain bearing strength of timber

, 2009
Compressive strength perpendicular to the grain of timber beams is a difficult problem as that not only many different load cases occur in practice but also there is the lack of a reliable model.
Leijten, AJM Ad, Leijten, A.J.M., Ad J. M. Leijten   +2 more
core   +1 more source

Elasto-visco-plastic material models and their industrial applications [PDF]

, 2009
The main goal of this work is the analysis of the procedure for material characterization aimed at elasto-visco-plastic models and their implementation in FEM codes.
Capasso, Daniela
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

On the Evaluation of the Mechanical Behaviour of Structural Glass Elements [PDF]

, 2005
Glass can be considered to be a high-technology engineering material with a multifunctional potential for structural applications. However, the conventional approach to the use of glass is often based only on its properties of transparency and ...
Teixeira-Dias, F., Costa, S., Miranda, M., Varum, H.   +3 more
core  

Çanakkale Kent Merkezindeki Anaokulu Bahçelerinin Peyzaj Unsurlarının İncelenmesi

Düzce University Faculty of Forestry Journal of Forestry
Okul öncesi eğitim dönemi bireyin yaşama dair en zengin deneyimlere sahip olduğu dönemdir ve içinde bulunduğu ortamın katacağı yaşantılar bireyin sonraki yaşamını önemli ölçüde etkiler. Bu dönem çocuğunun sağlıklı gelişimi için doğa mutlaka eğitim süreci
Seda Uygun, Özgür Kahraman
doaj   +1 more source