Results 171 to 180 of about 4,106,465 (337)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Marginal structural models for quantifying the causal effects of exposure to ambient air pollution on progression of CT emphysema in the MESA lung and MESA air studies. [PDF]

Am J Epidemiol
Malinsky D, Wang M, Heise R, Pistenmaa CL, Hoffman EA, Sheppard L, Szpiro AA, Laine A, Angelini ED, Smith BM, Kaufman JD, Barr RG.   +11 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Quasi-Maximum Likelihood for Estimating Structural Models. [PDF]

Stud Nonlinear Dyn Econom
Ben-Abdellatif M, Ben-Ameur H, Chérif R, Fakhfakh T.   +3 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Evaluation of the structural models of the human reference proteome: AlphaFold2 versus ESMFold. [PDF]

Curr Res Struct Biol
Manfredi M, Savojardo C, Martelli PL, Casadio R.   +3 more
europepmc   +1 more source

Structural Model Update on the Patuha geothermal system, West Java, Indonesia [PDF]

Ezidin Reski, Taufik Al Amin, Yuris Ramadhan, Randy Wijaya Atmaja, Maxwell Wilmarth   +4 more
openalex   +1 more source

A STRUCTURAL EQUATION MODELING OF THE ASSESSMENT PRACTICES INVENTORY MODIFIED (APIM) SCALE: AN ASSESSMENT MODEL FOR HIGHER EDUCATION INSTITUTIONS

, 2020
Musa Matovu
openalex   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Molecular mechanism and structural models of protein-mediated copper transfer to the Arabidopsis thaliana ethylene receptor ETR1 at the ER membrane. [PDF]

Sci Rep
Dluhosch D, Kersten LS, Minges A, Schott-Verdugo S, Gohlke H, Groth G.   +5 more
europepmc   +1 more source