Results 61 to 70 of about 5,320,256 (311)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Structural co-modulation: An individualized measure of inter-component interactions in source-based morphometry

NeuroImage
Source-based morphometry (SBM) is a powerful multivariate method for identifying covarying structural brain networks. However, standard SBM provides only a single loading value per component for each subject, which limits the characterization of ...
Aline Kotoski, Najme Soleimani, Sir-Lord Wiafe, Spencer Kinsey, Vince Calhoun   +4 more
doaj   +1 more source

The Combination of Functional and Structural MRI Is a Potential Screening Tool in Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2018
Introduction: This study aimed to survey the discrimination power of parameters from cerebrospinal fluid (CSF) biomarkers, fluorodeoxyglucose uptake on PET (FDG-PET), structural magnetic resonance imaging (MRI), and functional MRI in high- and low-risk ...
Chun-Chao Huang, Chun-Chao Huang, Chun-Chao Huang, Chun-Chao Huang, Wei-Ming Huang, Wei-Ming Huang, Wei-Ming Huang, Chia-Hung Chen, Chia-Hung Chen, Chia-Hung Chen, Zong-Yi Jhou, Zong-Yi Jhou, Zong-Yi Jhou, The Alzheimer’s Disease Neuroimaging Initiative, Ching-Po Lin, Ching-Po Lin, Ching-Po Lin   +16 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A comparison of resting state EEG and structural MRI for classifying Alzheimer’s disease and mild cognitive impairment

bioRxiv, 2019
Alzheimer’s disease (AD) is a neurodegenerative disorder characterised by severe cognitive decline and loss of autonomy. AD is the leading cause of dementia. AD is preceded by mild cognitive impairment (MCI). By 2050, 68% of new dementia cases will occur
Francesca R. Farina, D. D. Emek-Savaş, Laura M. Rueda-Delgado, R. Boyle, H. Kiiski, G. Yener, R. Whelan   +6 more
semanticscholar   +1 more source

Multi-Channel 4D Parametrized Atlas of Macro- and Microstructural Neonatal Brain Development

Frontiers in Neuroscience, 2021
Structural (also known as anatomical) and diffusion MRI provide complimentary anatomical and microstructural characterization of early brain maturation.
Alena Uus, Irina Grigorescu, Maximilian Pietsch, Dafnis Batalle, Dafnis Batalle, Daan Christiaens, Daan Christiaens, Emer Hughes, Jana Hutter, Lucilio Cordero Grande, Lucilio Cordero Grande, Anthony N. Price, Jacques-Donald Tournier, Mary A. Rutherford, Serena J. Counsell, Joseph V. Hajnal, Joseph V. Hajnal, A. David Edwards, Maria Deprez   +18 more
doaj   +1 more source

Integration of Measures of Functional and Structural MRI

, 2009
Recent years have seen a renewed interest in brain anatomy in the neuroimaging community. Developments in techniques for structural MR acquisition and analysis have opened new opportunities for structural mapping of the living human brain. For example, high-resolution MR imaging can be used for "in vivo histology", techniques such as voxel-based ...
Johansen-Berg, H, Behrens, T, Jbabdi, S, Watkins, K   +3 more
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Identification of the Early Stage of Alzheimer's Disease Using Structural MRI and Resting-State fMRI

Frontiers in Neurology, 2019
Accurate prediction of the early stage of Alzheimer's disease (AD) is important but very challenging. The goal of this study was to utilize predictors for diagnosis conversion to AD based on integrating resting-state functional MRI (rs-fMRI) connectivity
S. H. Hojjati, A. Ebrahimzadeh, A. Babajani-Feremi   +2 more
semanticscholar   +1 more source