Results 71 to 80 of about 5,320,256 (311)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

MRI of the axial skeleton in spondyloarthritis: the many faces of new bone formation

Insights into Imaging, 2019
Spondyloarthritis has two hallmark features: active inflammation and structural lesions with new bone formation. MRI is well suited to assess active inflammation, but there is increasing interest in the role of structural lesions at MRI.
Frederiek Laloo, Nele Herregods, Jacob L. Jaremko, Philippe Carron, Dirk Elewaut, Filip Van den Bosch, Koenraad Verstraete, Lennart Jans   +7 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Predicting conversion from MCI to AD by integrating rs-fMRI and structural MRI

Comput. Biol. Medicine, 2018
Structural MRI (sMRI) and resting-state functional MRI (rs-fMRI) have provided promising results in the diagnosis of Alzheimer's disease (AD), though the utility of integrating sMRI with rs-fMRI has not been explored thoroughly.
S. H. Hojjati, A. Ebrahimzadeh, Ali Khazaee, A. Babajani-Feremi, Alzheimer's Disease Neuroimaging Initiative   +4 more
semanticscholar   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Fast, fully automated segmentation of thalamic nuclei from structural MRI

NeuroImage, 2019
The thalamus and its nuclei are largely indistinguishable on standard T1 or T2 weighted MRI. While diffusion tensor imaging based methods have been proposed to segment the thalamic nuclei based on the angular orientation of the principal diffusion tensor,
Jason H Su, Francis T. Thomas, W. Kasoff, T. Tourdias, Eun Young Choi, B. Rutt, M. Saranathan   +6 more
semanticscholar   +1 more source

Diagnosis and prognosis of Alzheimer's disease using brain morphometry and white matter connectomes

NeuroImage: Clinical, 2019
Accurate, reliable prediction of risk for Alzheimer's disease (AD) is essential for early, disease-modifying therapeutics. Multimodal MRI, such as structural and diffusion MRI, is likely to contain complementary information of neurodegenerative processes
Yun Wang, Chenxiao Xu, Ji-Hwan Park, Seonjoo Lee, Yaakov Stern, Shinjae Yoo, Jong Hun Kim, Hyoung Seop Kim, Jiook Cha   +8 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

USE OF STRUCTURAL MRI IN PATIENTS WITH MEDICALLY REFRACTORY SEIZURES [PDF]

Journal of IMAB, 2012
Introduction: Refractory epilepsy is common in patients with structural brain lesions including acquired disorders and genetic abnormalities. Recently, MRI is a precise diagnostic tool for recognition of different structural causes underlying medically ...
Ara G. Kaprelyan, Dimitar M. Minchev, Alexandra J. Tzoukeva, Margarita V. Grudkova, Radoslav Georgiev   +4 more
doaj  

7-Tesla MRI demonstrates absence of structural lesions in patients with vestibular paroxysmia

Frontiers in Neuroanatomy, 2015
Vestibular parxoysmia is rare vestibular disorder. A neurovascular cross-compression between the vestibulochochlear nerve and an artery seems to be responsible for short attacks of vertigo in this entity.
Paulus Stefan Rommer, Gerald eWiest, Claudia eKronnerwetter, Heidemarie eZach, Benjamin eLoader, Kirsten eElwischger, Siegfried eTrattnig   +6 more
doaj   +1 more source