Results 111 to 120 of about 1,140,542 (305)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Case Studies in Thermal EngineeringPorous media are widely used in scientific research and engineering applications, where the effective thermal conductivity (ETC) serves as a critical thermo-physical parameter governing heat transfer behaviors.
Kun Liu +5 more
doaj +1 more source
Modeling, Analysis, and Optimization Issues for Large Space Structures [PDF]
Topics concerning the modeling, analysis, and optimization of large space structures are discussed including structure-control interaction, structural and structural dynamics modeling, thermal analysis, testing, and ...
Amos, A. K. +2 more
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
EnergiesAirborne Wind Energy (AWE) systems offer benefits such as high altitude access to stronger and more stable winds, reduced environmental impact, and cost effective infrastructure.
Yanjun Lv +4 more
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Optimization of fiber reinforced structures to satisfy aeroelastic requirements [PDF]
A numerical procedure was developed for minimizing the structural mass of an aircraft structure which must have a specified minimum flutter velocity or divergence velocity. During the optimization process the arrangement of the structural members remains
Rudisill, C. S.
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Data-driven modeling on anisotropic mechanical behavior of brain tissue with internal pressure
Defence TechnologyBrain tissue is one of the softest parts of the human body, composed of white matter and grey matter. The mechanical behavior of the brain tissue plays an essential role in regulating brain morphology and brain function.
Zhiyuan Tang +5 more
doaj +1 more source