Results 111 to 120 of about 5,411,731 (260)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

A survey on handling computationally expensive multiobjective optimization problems using surrogates: non-nature inspired methods

, 2015
Computationally expensive multiobjective optimization problems arise, e.g. in many engineering applications, where several conflicting objectives are to be optimized simultaneously while satisfying constraints.
Sindhya, Karthik, Miettinen, Kaisa, Tabatabaei, Mohammad, Hakanen, Jussi, Markus Hartikainen, Kaisa Miettinen, Karthik Sindhya, Hartikainen, Markus, Jussi Hakanen, Mohammad Tabatabaei   +9 more
core   +1 more source

A general and novel approach for predicting the effective thermal conductivity for randomly generated porous media by solving inverse heat conduction problems

Case Studies in Thermal Engineering
Porous media are widely used in scientific research and engineering applications, where the effective thermal conductivity (ETC) serves as a critical thermo-physical parameter governing heat transfer behaviors.
Kun Liu, Yuxuan Li, Jiawen Ren, Lei Wang, Chengbao Sun, Miao Cui   +5 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Structural shape optimization using evolution strategies

, 1999
Summarization: The objective of this paper is to investigate the efficiency of combinatorial optimization methods and in particular algorithms based on evolution strategies, when incorporated into shape optimization problems.
Papadrakakis, Manolis(http://viaf.org/viaf/305343444), Yiannis Tsompanakis, Tsompanakis, Y, Papadrakakis, M, Lagaros, Nikos D(http://viaf.org/viaf/269404562), Lagaros, ND   +5 more
core   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Trajectory Optimization for Airborne Wind Energy Systems Based on a Multi-Strategy Improved Salp Swarm Algorithm

Energies
Airborne Wind Energy (AWE) systems offer benefits such as high altitude access to stronger and more stable winds, reduced environmental impact, and cost effective infrastructure.
Yanjun Lv, Yan Pang, Zifeng Sun, Chenghao Zou, Yupeng Yang   +4 more
doaj   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

High-viscosity microenvironment inhibits endocytosis of drug-loaded nanoparticles in cancer cells

Nano Research
Drug-loaded nanoparticles (DLNPs) enhance intracellular drug accumulation through endocytosis and are widely used in chemotherapy research. Despite progress, the therapeutic efficacy of DLNPs remains limited due to the complexity of the in vivo ...
Guanlin Zhou, Chengwei Wu, Wei Zhang
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source