Results 61 to 70 of about 1,140,542 (305)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Inverse design of mechanical metamaterial achieving a prescribed constitutive curve
Theoretical and Applied Mechanics LettersBesides exhibiting excellent capabilities such as energy absorption, phase-transforming metamaterials offer a vast design space for achieving nonlinear constitutive relations. This is facilitated by switching between different patterns under deformation.
Zongliang Du +6 more
doaj +1 more source
Optimization of sharp and viewing-angle-independent structural color [PDF]
, 2015 Structural coloration produces some of the most brilliant colors in nature and has many applications. However, the two competing properties of narrow bandwidth and broad viewing angle have not been achieved simultaneously in previous studies.
Hsu, Chia Wei +3 more
core +2 more sources
Optimizing disordered crystal structures
Acta Crystallographica Section C Structural Chemistry, 2023 A mixed-crystal full-molecule disorder situation is revisited in Parkin et al. [Acta Cryst. (2023), C79, 77–82]. A new interpretation of the data leads to the conclusion that the crystal structure is more likely to be a three-component superposition of enantiomers and the meso isomer of an organic compound and the article is thus a good learning ...
openaire +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
On a New Type of Information Processing for Efficient Management of Complex Systems
, 2007 It is a challenge to manage complex systems efficiently without confronting NP-hard problems. To address the situation we suggest to use self-organization processes of prime integer relations for information processing.
Korotkikh, Galina, Korotkikh, Victor
core +1 more source
Improved dynamical particle swarm optimization method for structural dynamics [PDF]
, 2019 A methodology to the multiobjective structural design of buildings based on an improved particle swarm optimization algorithm is presented, which has proved to be very efficient and robust in nonlinear problems and when the optimization objectives are in
Annicchiarico, W. C. +1 more
core +2 more sources
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
International Journal of Smart and Nano MaterialsPiezoelectric energy harvesting is vital for powering microelectronic systems, with great potential for dual-scale structures. However, implementing such designs presents challenges, such as multiphysics coupling, performance measurement, and design ...
Erke Zhang +3 more
doaj +1 more source
, 1971 The non-linear programming algorithms for the minimum weight design of structural frames are presented in this thesis. The first, which is applied to rigidly jointed and pin jointed plane frames subject to deflexion constraints, consists of a search in a feasible design space.
openaire +1 more source