Results 71 to 80 of about 5,411,731 (260)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Concurrent topology optimization of piezoelectric composite structures for high performance energy harvesting

International Journal of Smart and Nano Materials
Piezoelectric energy harvesting is vital for powering microelectronic systems, with great potential for dual-scale structures. However, implementing such designs presents challenges, such as multiphysics coupling, performance measurement, and design ...
Erke Zhang, Zheng Ni, Dazhi Wang, Xiaopeng Zhang   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Numerical Study of Vortex-Excited Vibration of Flexible Cylindrical Structures with Surface Bulge

Journal of Marine Science and Engineering
This study conducted numerical simulations of three-dimensional vortex-induced vibrations (VIV) on cylindrical bodies with various surface protrusion coverage rates, systematically investigating the impact of coverage and protrusion height on the ...
Jiahe Zou, Bo Zhou, Hui Liu, Wenxin Yi, Conghong Lu, Wenqing Luo   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Optimization of acoustic response : a numerical and experimental comparison

, 2000
Acoustic optimization within structural dynamics involves automatic changes of structural design variables such as geometric dimensions, shell thickness, material parameters, fiber density and orientation angles, and others to obtain minimum noise or a ...
Tinnsten, Mats,
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A multi-mode thermoregulating fabric with integrated passive/active temperature control capabilities

Nano Research
Wearable thermoregulating fabrics with multi-mode temperature control are of great significance in response to extreme cold weather. Herein, a multi-mode thermoregulating thermoplastic polyurethane (TPU)/MXene fabric (TMF), integrating passive radiation ...
Jingwen Dong, Bing Zhou, Gaojie Han, Jin Gao, Xianhu Liu, Yuezhan Feng, Chuntai Liu, Changyu Shen   +7 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Design optimization based on state problem functionals [PDF]

, 2015
This paper presents a general mathematical structure for design optimization problems, where state problem functionals are used as design objectives.It extends to design optimization the general model of physical theories pioneered by Tonti (1972, 1976 ...
Klarbring, Anders, Klarbring, Anders,
core   +1 more source