Results 61 to 70 of about 5,411,731 (260)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Structural optimization of modular product families with application to car space frame structures

, 2006
This paper extends classical structural optimization from single-product optimization to optimization of a whole family of products that have common modules. It integrates the family commonality problem with the finite element models of the structures. A
A. Klarbring, Torstenfelt, Bo,, Klarbring, Anders,, B. Torstenfelt   +3 more
core   +1 more source

Centrifugal Inertia‐Induced Directional Alignment of AgNW Network for Preparing Transparent Electromagnetic Interference Shielding Films with Joule Heating Ability

Advanced Science
Transparent electromagnetic interference (EMI) shielding is highly desired in specific visual scenes, but the challenge remains in balancing their EMI shielding effectiveness (SE) and optical transmittance.
Weijun Zhao, Jingwen Dong, Zhaoyang Li, Bing Zhou, Chuntai Liu, Yuezhan Feng   +5 more
doaj   +1 more source

Inverse design of mechanical metamaterial achieving a prescribed constitutive curve

Theoretical and Applied Mechanics Letters
Besides exhibiting excellent capabilities such as energy absorption, phase-transforming metamaterials offer a vast design space for achieving nonlinear constitutive relations. This is facilitated by switching between different patterns under deformation.
Zongliang Du, Tanghuai Bian, Xiaoqiang Ren, Yibo Jia, Shan Tang, Tianchen Cui, Xu Guo   +6 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Structural optimization of product families subjected to multiple crash load cases

, 2010
This paper discusses the problem of structural optimization of product families subjected to multiple load cases, evaluated by computationally costly finite element analysis. Product families generally have a complex composition of shared components that
Larsgunnar Nilsson, Michael Öman, Öman, Michael,, Nilsson, Larsgunnar,   +3 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

An improved critical constraint method for structural optimization of product families

, 2011
This paper discusses important improvements in the efficient Critical Constraint Method (CCM) for the optimization of structural product families subjected to multiple crash load cases. The method was first presented by Öman and Nilsson (Struct Multidisc
Larsgunnar Nilsson, Michael Öman, Öman, Michael,, Nilsson, Larsgunnar,   +3 more
core   +1 more source

A new data-driven topology optimization framework for structural optimization

, 2020
The application of structural topology optimization with complex engineering materials is largely hindered due to the complexity in phenomenological or physical constitutive modeling from experimental or computational material data sets.
Zhan, Haifei, Zhang, Weihong, Bai, Jinshuai, Zhu, Jihong, Gu, Yuantong, Zhou, Ying, Wang, Qingxia   +6 more
core   +1 more source

Thermosensitive crystallization-boosted thermoelectric hydrogels for self-powered sensing and intelligent perception applications

Nano Research
Wearable sensing technology has seen widespread use in health monitoring, environmental perception, and human–machine interaction. Among them, sensors that can actively harvest energy from their application scenarios to achieve self-powering are ...
Pengyuan Kang, Yuke Zhang, Qiuxi Sun, Ziyan Lu, Yalong Wang, Hu Liu, Chuntai Liu, Changyu Shen   +7 more
doaj   +1 more source