Results 61 to 70 of about 3,439,845 (290)
Sr. Realista estructural, tenemos un problema: la carga ontológica de las matemáticas
Principia: An International Journal of Epistemology, 2010 The aim of this note is to undermine structural realism by testing the soundness of its main claim. If scientific theories represent the structure of the world, structural realism needs a general account of representation.
Carlos M. Madrid Casado
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
El realismo estructural a debate: matemáticas, ontología y representación
Revista de Filosofia, 2009 The aim of this paper is to undermine structural realism by testing the soundness of its three main theses. The first section presents the epistemic and ontic forms of structural realism.
Carlos M. Madrid Casado
doaj
, 2005 What is the ultimate nature of reality? This paper defends an answer in terms of informational realism (IR). It does so in three stages. First, it is shown that, within the debate about structural realism (SR), epistemic (ESR) and ontic (OSR) structural ...
Floridi, Luciano
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Epistemic Structural Realism and Poincare's Philosophy of Science [PDF]
, 2013 Recent discussions of structuralist approaches to scientific theories have stemmed primarily from Worrall's (1989), in which he defends a position (since characterized `epistemic structural realism') whose historical roots he attributes to Poincare.
Brading, Katherine, Crull, Elise
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Ontological Priority: The Conceptual Basis of Non-eliminative, Ontic Structural Realism
, 2011 The number of positions identified with structural realism in philosophical debates about scientific knowledge has grown significantly in the past decade, particularly with respect to the metaphysical or “ontic” approach (OSR).
Chakravartty, Anjan, Anjan Chakravartty
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Scientific Realism and the Inevitability of Science [PDF]
, 2007 : This paper examines the question of whether scientific realism is committed to the inevitability of science or is consistent with claims of the contingency of science.
Sankey, Howard, Sankey, H
core +1 more source