Results 61 to 70 of about 3,620,319 (299)

Structural Realism and Abductive-Transcendental Arguments [PDF]

open access: yes, 2007
The paper deals with an attempt to present an “abductive-transcendental” argument in favour of a particular version of structural realism (SR), dubbed Intermediate SR.
Lyre, Holger
core  

Sr. Realista estructural, tenemos un problema: la carga ontológica de las matemáticas

open access: yesPrincipia: An International Journal of Epistemology, 2010
The aim of this note is to undermine structural realism by testing the soundness of its main claim. If scientific theories represent the structure of the world, structural realism needs a general account of representation.
Carlos M. Madrid Casado
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Informational Realism [PDF]

open access: yes, 2005
What is the ultimate nature of reality? This paper defends an answer in terms of informational realism (IR). It does so in three stages. First, it is shown that, within the debate about structural realism (SR), epistemic (ESR) and ontic (OSR) structural ...
Floridi, Luciano
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

El realismo estructural a debate: matemáticas, ontología y representación

open access: yesRevista de Filosofia, 2009
The aim of this paper is to undermine structural realism by testing the soundness of its three main theses. The first section presents the epistemic and ontic forms of structural realism.
Carlos M. Madrid Casado
doaj  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Epistemic Structural Realism and Poincare's Philosophy of Science [PDF]

open access: yes, 2013
Recent discussions of structuralist approaches to scientific theories have stemmed primarily from Worrall's (1989), in which he defends a position (since characterized `epistemic structural realism') whose historical roots he attributes to Poincare.
Brading, Katherine, Crull, Elise
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Ontological Priority: The Conceptual Basis of Non-eliminative, Ontic Structural Realism

open access: yes, 2011
The number of positions identified with structural realism in philosophical debates about scientific knowledge has grown significantly in the past decade, particularly with respect to the metaphysical or “ontic” approach (OSR).
Chakravartty, Anjan, Anjan Chakravartty
core   +1 more source

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