Results 71 to 80 of about 3,439,845 (290)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
How not to be a Realist or why we Ought to Make it Safe for Closet Structural Realists to Come out. [PDF]
, 2010 When it comes to name-calling, structural realists have heard pretty much all of it. Among the many insults, they have been called ‘empiricist anti-realists’ but also ‘traditional scientific realists’.
Votsis, Ioannis
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Zagadnienia Filozoficzne w Nauce, 2005 The purpose of this paper is to discuss the various types of physical universe which could exist according to modern mathematical physics. The paper begins with an introduction that approaches the question from the viewpoint of ontic structural realism ...
Gordon McCabe
doaj
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Emergent Geometry in Complex Systems from Relational Dynamics: The Classical Setting
AxiomsGeometry is typically treated as a primitive background structure within which physical processes unfold. In this work, we investigate an alternative possibility: that geometry can arise as a structural consequence of relational dynamics.
Ernesto Estrada
doaj +1 more source
Revisiting Poincaré’s conventionalism and anti-realism
Filosofia Unisinos, 2021 Poincaré’s philosophical conception and his contribution to the Philosophy of Science has been reconsidered since the recent rise of structural realism (SR), 18 years ago.
Susana Lucero
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Process Structural Realism, Instance Ontology, and Societal Order [PDF]
, 2008 Whitehead’s cosmology centers on the self-creation of actual occasions that perish as they come to be, but somehow do combine to constitute societies that are persistent agents and/or patients. “Instance Ontology” developed by D.W.
Earley, Joseph
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