Results 31 to 40 of about 84,067 (219)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

A Hybrid Optimization Method for Rebar Cutting in Structural Reinforcement

open access: yesBuildings
With the growing application of digital technologies in construction, reinforcement detailing and cutting are becoming increasingly refined. However, existing cutting methods struggle to meet the dual requirements of low waste and high computational ...
Jindong Zhang   +2 more
doaj   +1 more source

The Impact of Transverse Confinement of RC Columns on the Seismic Response of the Reinforced Concrete Frame Structure

open access: yesBulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2022
The vertical structural components of RC frame buildings are the fundamental elements that ensure lateral stability of entire system under exceptional seismic loading situations.
Sococol Ion, Mihai Petru, Shams Ali
doaj   +1 more source

Development of Multi-Tee-Type Precast Concrete Slabs with Insulating Materials for Structural Safety at the Construction Stage

open access: yesApplied Sciences, 2021
Multi-tee-type precast concrete (PC) slab systems are widely used for the construction of modular high-load long-span buildings. However, the structural safety of the dapped end is uncertain, owing to the unanchored shear reinforcement at the ...
Jang-Woon Baek, Su-Min Kang
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Comparative Analysis of Building X's Fiber Polymer Composite and Conventional Method Beam Reinforcement Time Performance

open access: yesRekayasa Sipil
Initially, Building X in Jakarta functioned as a typical office building. Reinforcement was necessary because the building's purpose had changed to a bank office, which required a space for archives that necessitated a relatively large storage area.
Yopi lutfiansyah   +3 more
doaj   +1 more source

Study of epoxy composites and sisal fibers as reinforcement of reinforced concrete structure

open access: yesRevista IBRACON de Estruturas e Materiais, 2019
The application of structural reinforcement has presented a significant growth in the present days. The development of new materials for this purpose has aroused the interest of many researchers.
H. M. FRANCKLIN   +4 more
doaj   +2 more sources

Model tests on effect of bonded steel plate reinforcement of shield tunnels under different deformation conditions

open access: yesYantu gongcheng xuebao, 2020
Due to the impact of surrounding projects such as stacking and excavation, it has become a common problem for metro tunnels to produce large deformations.
LIU Xue-zeng 1, LAI Hao-ran 1, SANG Yun-long 2, 3, DUAN Jun-ming 1, DING Shuang 2, 3
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

open access: yesFEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng   +8 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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