Results 51 to 60 of about 3,676,467 (289)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Fiber-Reinforced Polymers as Reinforcement for Timber Structural Elements
, 2021 S.51-78This chapter provides a comprehensive summary of recent developments in the use of fiber-reinforced polymers (FRP) as reinforcement for timber elements and joints. The constituents of FRP composites are first introduced.
Yan, Libo +3 more
core +1 more source
Rekayasa SipilInitially, Building X in Jakarta functioned as a typical office building. Reinforcement was necessary because the building's purpose had changed to a bank office, which required a space for archives that necessitated a relatively large storage area.
Yopi lutfiansyah +3 more
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
, 2014 In the empirical methods for reinforcement design of underground excavations, an even distribution of rock bolts is generally recommended. This work proves that this design is not necessarily optimal and shows how the state-of-the-art reinforcement ...
Ghabraie, K., Nguyen, T., Tran-Cong, T.
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Improving Exploration in Reinforcement Learning through Domain Knowledge and Parameter Analysis [PDF]
, 2010 This thesis presents novel work on how to improve exploration in reinforcement learning using domain knowledge and knowledge-based approaches to reinforcement learning.
Grzes, Marek
core +5 more sources
Decentralized Bayesian reinforcement learning for online agent collaboration [PDF]
, 2012 Solving complex but structured problems in a decentralized manner via multiagent collaboration has received much attention in recent years. This is natural, as on one hand, multiagent systems usually possess a structure that determines the allowable ...
Farinelli, A. +6 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Dog Behaviour - Effect of Delay To Reinforcement [PDF]
, 2012 Dogs were fed dry food as reinforcement and were required to touch a wand with their nose to get that reinforcement. In the first study, half the dogs were given immediate reinforcement, while for the remaining dogs reinforcement was delayed by two ...
Lord, Sarah
core