Results 71 to 80 of about 3,676,467 (289)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Applied SciencesPremature debonding between carbon fiber-reinforced polymer (CFRP) and concrete is a critical issue in structural reinforcement applications, often leading to a significant reduction in the load-carrying capacity of the system.
Riad Babba +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Fully reversible reinforcement of softwood beams with unbonded composite plates [PDF]
, 2016 In this paper, results of flexure tests aimed at improving the structural behaviour of softwood beams reinforced with unglued composite plates and at developing an effective alternative to the use of organic resins are presented.
Borri, Antonio +3 more
core +1 more source
Evaluation of seismic performance of an educational institution using nonlinear dynamic analysis
Revista Ingeniería de ConstrucciónCurrently, there are a large number of old educational institutions that are still in operation and have been built without taking into account seismic-resistant criteria.
Ariana Yvett Paredes Cruz +2 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Mechanical properties of tree roots for soil reinforcement models [PDF]
, 2001 Evidence from forestry has shown that part of the forest floor bearing capacity is delivered by tree roots. The beneficial effect however varies and diminishes with increasing number of vehicle passes. Roots potential for reinforcing the soil is known to
Cofie, P.
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Applied SciencesThe utilization of ecological and cost-effective construction materials has emerged as a critical necessity in contemporary circumstances. It is essential to investigate the use of repair mortar as opposed to epoxy, which offers adhesion to concrete, to ...
Dursun Bakir +2 more
doaj +1 more source