Results 61 to 70 of about 3,676,467 (289)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Journal of Civil Engineering and Management, 2020 This paper investigates structural performance of five reinforcement concrete (RC) box-girders under a combination loading of bending, shear and torsion, applying the structural stressing state theory.
Hengheng Xiao +4 more
doaj +1 more source
Virtual and Physical Prototyping, 2022 The Eggshell fabrication process combines the 3D printing of formwork with the simultaneous casting of a fast-hardening concrete. One limiting factor to reaching mass-market adoption is a suitable reinforcing strategy.
Lukas Gebhard +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Suboptimal Choice Behaviour across Different Reinforcement Probabilities [PDF]
, 2015 Six adult roosters’ choice behaviour was investigated across a series of five experimental conditions and a series of replication of the same five experimental conditions. Stagner and Zentall (2010) found that pigeons prefer to choose an alternative with
Yang, Le
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Layout Of Structural Systems And Reinforcement Detailing Principles Of Reinforced Concrete Structures [PDF]
, 2015 Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2006Thesis (M.Sc.) -- İstanbul Technical University, Institute of Science and Technology, 2006Ülkemizde en son meydana gelen depremler sonucu görülen hasarlar, betonarme ...
Yılmaz, Tuncay
core
Corrosion protection of reinforcing steel reinforced concrete structures of transport structures
Russian journal of transport engineering, 2020 The influence of reinforcing steel corrosion on the durability of reinforced concrete structures of transport structures and the degree of knowledge of this problem is considered. It is specified that the protection of reinforcing steel from corrosion is not able to completely replace the correct design and use of high-strength concrete. But it is able
Alexander Bulkov +2 more
openaire +1 more source