Results 91 to 100 of about 1,015,002 (311)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Structural stability of the hepatitis C model with the proliferation of infected and uninfected hepatocytes

Mathematical and Computer Modelling of Dynamical Systems
The structural stability of the hepatitis C model with the proliferation of infected and uninfected hepatocytes is investigated in this paper. The model is clinically verified to accurately reflect the viral dynamics of hepatitis C.
Z. Navickas, R. Marcinkevicius, I. Telksniene, T. Telksnys, M. Ragulskis   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cation ratio of soil structural stability (CROSS)

, 2010
Sodium salts tend to dominate salt-affected soils and groundwater in Australia and therefore, sodium adsorption ratio (SAR) is being used to parameterize soil sodicity and the effects of sodium on soil structure.
Rengasamy, Pichu, Marchuk, Alla, Pichu Rengasamy, Marchuk, A., Alla Marchuk, Rengasamy, P.   +5 more
core   +1 more source

Rheological Characterization of Structural Stability for Black Soils from Northeast China

Agronomy
Soil structural stability is fundamentally linked to soil functionality and sustainable productivity. Rheological properties describe the deformation and flow behavior of soil under external stress, playing a crucial role in understanding soil structure ...
Jian Sun, Lin Zhou, Yuyang Yan, Chenyang Xu, Zhe Liu, Zhenghong Yu, Jiangwen Li, Feinan Hu   +7 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Mechanical Response Analysis of Semi-Detached Movable Roof and Optimization of Subrail Foundation Reinforcement

Buildings
Ground-based movable roof construction offers advantages such as flexible adjustment, energy conservation, environmental protection, improved comfort, structural stability, and high space utilization.
Ziguang Zhang, Ankang Hu, Xiaopeng Li, Shuai Kang, Cheng Zhang   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Structural stability during remelting of foundry binary alloys

Литьë и металлургия
A nanostructural mechanism of structural stability during remelting of foundry binary alloys has been developed. This mechanism is determined by the stability of the centers of crystallization of microcrystals of α‑phases and β‑phases.
E. I. Marukovich, V. Yu. Stetsenko, A. V. Stetsenko   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source