Results 121 to 130 of about 1,028,024 (317)

Total potential energy minimization method in structural analysis considering material nonlinearity [PDF]

open access: yes, 2017
Minimum potential energy principle is the basis of the most of the well-known traditional techniques used in the structural analysis. This principle determines the equilibrium conditions of systems with reference to minimization of the sum of the total ...
Bekdaş, Gebrail   +5 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Startlink building system and connections for fibre reinforced polymer structures [PDF]

open access: yes
The research presented in this thesis examines various aspects on connections and joints in Pultruded Fibre Reinforced Polymeric (PFRP) structures. The work is divided into two experimental investigations on the determination of pin-bearing strength ...
Zafari, Behrouz
core  

An Alternative Structural System For Low Rise Buildings And A Method Proposed For Lateral Load Analysis [PDF]

open access: yes, 2015
Tez (Doktora) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2003Thesis (PhD) -- İstanbul Technical University, Institute of Science and Technology, 2003Geleneksel yapım sistemlerine alternatif olarak, teknoloji bakımından gelişmiş ülkelerden ...
Sesigür, Haluk
core  

From Material Level to Structural Use of Mineral-Based Composites—An Overview

open access: yesAdvances in Civil Engineering, 2010
This paper surveys different material combinations and applications in the field of mineral-based strengthening of concrete structures. Focus is placed on mechanical behaviour on material and component levels in different cementitious composites; with ...
Katalin Orosz   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Structural analysis of the proposed multi-layer dodecarotor UAV

open access: yesInternational Journal of Aeronautics and Astronautics, 2020
In this study, structural analysis of a multilayer dodecarotor drone system is presented. In the structural analysis performed with the finite element method, a multi-body analysis was performed for the major components that make up the system in order ...
Nihat Çabuk   +2 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Potential structural material problems in a hydrogen energy system [PDF]

open access: yes, 1975
Potential structural material problems that may be encountered in the three components of a hydrogen energy system - production, transmission/storage, and utilization - were identified.
Nelson, H. G.   +5 more
core   +1 more source

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