Results 131 to 140 of about 1,028,024 (317)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Discover SustainabilityA gradual increase in material consumption undermines environmental sustainability, particularly in resource-dependent nations. This study examines whether Namibia’s economic development is decoupled from its material footprint.
Helvi Nyete Johannes +2 more
doaj +1 more source
The Influence of Material Control Systems on Remaining Materials in Structural Work
Journal La MultiappDigital transformation has increased operational efficiency infrastructure critical, but at the same time also open new loophole against attack increasingly complex and destructive cyberspace. This study aims to identify spectrum threat cyber targeting infrastructure critical, analyzing vulnerability accompanying systemic, as well evaluate strategy ...
Joan Riadi +2 more
openaire +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Structural evaluation of a novel box beam system of Pultruded Fibre Reinforced Polymer shapes [PDF]
Presented in this thesis is an evaluation of a novel box beam system of Pul- truded Fibre Reinforced Polymer (PFRP) shapes. The flat-pack modular beam system consists of separate PFRP flange and web shapes joined together with a new method of ...
Evernden, Mark
core
Development of effective Structural Health Monitoring strategies using Self Organizing Map and Index Based Reasoning [PDF]
, 2009 Structural Health Monitoring (SHM) systems are expected to reduce the mishap rate of the Unmanned Aerial Vehicles (UAV). In this study, frequency responses of structures were analyzed to evaluate the health of the tubes of a small 4 rotor helicopter and ...
core +1 more source
Resilient structures: materials components systems
Structure and Infrastructure Engineering, 2023 openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Reliability Analysis of an Ultrasonic Guided Wave Based Structural Health Monitoring System for a Carbon Fibre Reinforced Thermoplastic Torsion-box [PDF]
, 2017 Certification is the key step towards the implementation of structural health monitoring (SHM) as part of condition based maintenance programmes of aircraft fleets.
Ochôa, Pedro (author) +2 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source