Results 141 to 150 of about 1,028,024 (317)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Definitions of Resistance and Deformation Capacity for Non-Sway Steel and Composite Structures [PDF]

, 2002
Resistance, stiffness and deformation capacity are three characteristics describing the behaviour of (statically loaded) structures. The stiffness relates mostly to the serviceability of the structure.
Vrouwenvelder, A.C.W.M., Vrouwenvelder, A.C.W.M. (author), Van Herwijnen, F. (author), Snijder, H.H. (author), Vrouwenvelder, ACWM, Van Herwijnen, F., Snijder, H.H., Steenhuis, C.M., Herwijnen, van, F., Herwijnen, F Frans van, Snijder, HH Bert, Steenhuis, CM, Steenhuis, C.M. (author)   +12 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Versatile and easy-to-assemble measurement system for impedance-based structural health monitoring [PDF]

, 2011
In this paper we present a versatile and easy-to-assemble measurement system for structural health monitoring (SHM) based on the electromechanical impedance (EMI) technique.
Baptista, F. G. [UNESP], Inman, D. J., Lopes, V. [UNESP], Oki, N. [UNESP], Turra, A. E. [UNESP], Vieira Filho, Jozué [UNESP]   +5 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Development of Materials Integration System for Structural Materials

International Conference on Computational & Experimental Engineering and Sciences, 2019
M. Watanabe*, S. Minamoto, T. Kadohira, K. Ito, M. Demura   +4 more
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Embodied Resource Flows and Product Flows: Combining the Absorbing Markov Chain with the Input-Output Model [PDF]

We develop the absorbing Markov chain (AMC) for describing in detail the network of paths through an industrial system taken by an embodied resource from extraction through intermediate products and finally consumer products.
Faye Duchin, Stephen H. Levine
core  

On the multifunctional performance of structural batteries [Elektronisk resurs] [PDF]

, 2019
The structural battery composite is a composite material that can store electrical energy (i.e. work as a battery) while simultaneously provide mechanical integrity in a structural system.
Carlstedt, David,
core