Results 131 to 140 of about 395,744 (213)

Completely resolved structural variants by optical genome mapping with adaptive sampling from CNV discovery. [PDF]

NPJ Genom Med
Fu L, Kim CA, Tokita M, Miyata Y, Okamoto N, Makita Y, Osaka H, Fujimoto A, Daida A, Nirei J, Udagawa N, Hayakawa S, Deguchi K, Fukuda M, Matsumoto H, Akasaka M, Okada J, Misumi Y, Kido J, Suzuki T, Aoi H, Seyama R, Hamanoue H, Mitsuhashi S, Ohori S, Saida K, Inoue Y, Hamanaka K, Tsuchida N, Uchiyama Y, Koshimizu E, Miyatake S, Mizuguchi T, Itakura A, Harada N, Fujita A, Matsumoto N.   +36 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Compound heterozygous structural variants resulting in CNTNAP2 biallelic loss-of-function: rare mechanisms unveiled by genome sequencing. [PDF]

Hum Genomics
Fauqueux J, Caumes R, Colson C, Trauffler A, Cleuziou P, Thuillier C, Planté-Bordeneuve P, Tessarech M, Ghoumid J, Smol T.   +9 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Tumor-informed liquid biopsy detection of structural variants in high grade serous ovarian cancer. [PDF]

Oncoscience
Li J, Takamatsu S, Brodsky AL, Welte T, Calzoncinth K, Vuttaradhi VK, Celestino J, Lawson B, Hillman RT.   +8 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Analysis of error profiles of indels and structural variants in deep-sequencing data. [PDF]

Cell Genom
Shao Y, Tran Q, Feng Y, Kolekar P, Liu Y, Liang Z, Fan L, McBride A, Jones T, Cameron A, Mulder H, Ji L, Huang BJ, Klco JM, Meshinchi S, Zhang J, Carroll WL, Loh ML, Easton J, Brown PA, Ma X.   +20 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source