Results 181 to 190 of about 908,392 (296)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

SVCROWS: a user-defined tool for interpreting significant structural variants in heterogeneous datasets. [PDF]

Nucleic Acids Res
Brown N, Danis C, Ahmedjanova V, Guler JL.   +3 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Rare Structural Variants Uncovered by Optical Genome Mapping in Multisystem Inflammatory Syndrome in Children (MIS-C). [PDF]

Adv Genet (Hoboken)
Brownstein CA, van der Made CI, Cabral K, Rockowitz S, Kang D, Schieck M, Pang AWC, Robinson JM, Hastie AR, Chaubey A, C.O.V.I.D19hostgenomeS.V. Consortium, Hoischen A, Beggs AH, Adebamowo CA, Andalibi A, Bacanu SA, Bafna V, Bahl J, Barseghyan H, Beggs A, Burdette L, Butte M, Constantoulakis P, Crandall KA, Dehkordi SR, Dennis M, Fang G, Fedrigo O, Finlay D, Goldman MA, Gurusamy U, Hayes V, Hickey G, Hoischen A, Illig T, Ioannidis A, Jarvis E, Koizumi N, Kolhe R, Laamarti M, Labranche C, Leibel S, Levy B, Loose M, Mello C, Nasir J, Phung TL, Rao CPV, Ross T, Sahajpal NS, Shamanna RK, Soto DC, Trablesi A, Wang ZX, Williams SL, Wright V, Zhao H, Zody M.   +57 more
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Compound Heterozygous Structural Variants in Cases with Unsolved PRKN-Associated Parkinson's Disease. [PDF]

Mov Disord
Fant A, Trova S, Monfrini E, Treves G, Musacchia F, Landuzzi F, Mandich P, Amoroso A, Sanges R, Pandolfini L, Cavallieri F, Valzania F, Fioravanti V, Di Rauso G, Brescia G, Valente EM, Tiranti V, Romito LM, Reale C, Garavaglia B, Elia AE, Cavalli A, Di Fonzo A, Vecchi M, Gustincich S.   +24 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Screening of Hidden Pathogenic Structural Variants in PRKN. [PDF]

Mov Disord
Daida K, Cogan G, Tesson C, Lesage S, Schaake S, Balck A, Trinh J, Lohmann K, Malik L, Baker B, Paquette K, Moller A, Sue C, Funayama M, Hattori N, Singleton A, Klein C, Brice A, Billingsley KJ, Blauwendraat C.   +19 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Structural Variants: Mechanisms, Mapping, and Interpretation in Human Genetics. [PDF]

Genes (Basel)
Pande S, Dawood M, Grochowski CM.
europepmc   +1 more source