Results 191 to 200 of about 4,271,392 (311)

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Classifying germline and somatic structural variants in tumor-only contexts using GaTSV. [PDF]

STAR Protoc
Chukwu W, Lee S, Crane A, Zhang S, Wala J, Dakhama O, Raskind G, Sun J, Beroukhim R, Dubois F, Dalin S.   +10 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Mapping structural variants in Populus tomentosa reveals adaptive signatures and improves prediction of wood properties. [PDF]

Nat Commun
Zhong L, Zhang D, Huang R, Zhou J, Zhang W, Li L, Jin Z, Zhang M, Tian C, Yuan M, Zhang Y, Li P, Xiao L, Quan M, Zhang D, Li J, Du Q.   +16 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

A course-undergraduate research experience (CURE) to explore the effect of structural variants on gene expression in C. elegans balancers. [PDF]

PLoS One
Maroilley T, Barbosa VRA, Mascarenhas R, Ferris S, Diao C, AlAwadhi F, Aldakheel S, Ali A, Alkanderi D, Alshatti M, Alsuwaileh S, Bui R, Chai B, Dsouza L, Nezhad PE, Garcia-Volk E, Haq Z, Hossain S, Johnson G, Kotikalapudi N, Lalani I, Lenz C, Louie T, Moore S, Patel S, Prasai S, Qureshi R, Rahmani F, Shakir B, Ahamed SS, Tran HA, Waziha R, Wood CM, Zbinden S, Anderson D, Tarailo-Graovac M.   +35 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Non-coding structural variants disrupting conserved PITX2 enhancer loci in Axenfeld-Rieger syndrome. [PDF]

Eur J Hum Genet
Mitchell LA, Schmidt J, Souzeau E, Knight LSW, Maxwell G, Dubowsky A, Lim R, Formaini E, Welland M, Simons C, MacArthur DG, Wiggs JL, Craig JE, Siggs OM.   +13 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Variant Curation of the Largest Compendium of <i>FOXL2</i> Coding and Noncoding Sequence and Structural Variants in BPES. [PDF]

Hum Mutat
Matton C, Van De Velde J, De Bruyne M, Van De Sompele S, Hooghe S, Syryn H, Bauwens M, D Haene E, Dheedene A, Cools M, Komatsuzaki S, Preizner-Rzucidło E, Ross A, Armstrong C, Watkins W, Shelling A, Vincent AL, Cassiman C, Vermeer S, Bunyan DJ, Verdin H, De Baere E.   +21 more
europepmc   +1 more source