Results 221 to 230 of about 4,271,392 (311)

Alpha-synuclein structural variants driving tau pathology and disease interaction. [PDF]

Neural Regen Res
Sun C.
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Author Correction: Complex de novo structural variants are an underestimated cause of rare disorders. [PDF]

Nat Commun
Jung H, Yang TP, Walker S, Danecek P, Garcia-Salinas OI, Neville MDC, Christopher J, Cortés-Ciriano I, Firth H, Scally A, Hurles M, Campbell P, Rahbari R.   +12 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Completely resolved structural variants by optical genome mapping with adaptive sampling from CNV discovery. [PDF]

NPJ Genom Med
Fu L, Kim CA, Tokita M, Miyata Y, Okamoto N, Makita Y, Osaka H, Fujimoto A, Daida A, Nirei J, Udagawa N, Hayakawa S, Deguchi K, Fukuda M, Matsumoto H, Akasaka M, Okada J, Misumi Y, Kido J, Suzuki T, Aoi H, Seyama R, Hamanoue H, Mitsuhashi S, Ohori S, Saida K, Inoue Y, Hamanaka K, Tsuchida N, Uchiyama Y, Koshimizu E, Miyatake S, Mizuguchi T, Itakura A, Harada N, Fujita A, Matsumoto N.   +36 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Compound heterozygous structural variants resulting in CNTNAP2 biallelic loss-of-function: rare mechanisms unveiled by genome sequencing. [PDF]

Hum Genomics
Fauqueux J, Caumes R, Colson C, Trauffler A, Cleuziou P, Thuillier C, Planté-Bordeneuve P, Tessarech M, Ghoumid J, Smol T.   +9 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Tumor-informed liquid biopsy detection of structural variants in high grade serous ovarian cancer. [PDF]

Oncoscience
Li J, Takamatsu S, Brodsky AL, Welte T, Calzoncinth K, Vuttaradhi VK, Celestino J, Lawson B, Hillman RT.   +8 more
europepmc   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source