Results 61 to 70 of about 4,271,392 (311)

Clinical Utility of Optical Genome Mapping for Improved Cytogenomic Analysis of Gliomas

Biomedicines
A glioma is a solid brain tumor which originates in the brain or brain stem area. The diagnosis of gliomas based on standard-of-care (SOC) techniques includes karyotyping, fluorescence in situ hybridization (FISH), and chromosomal microarray (CMA), for ...
Harmanpreet Singh, Nikhil S. Sahajpal, Ashis K. Mondal, Stephanie L. Burke, Jaspreet Farmaha, Ahmet Alptekin, Ashutosh Vashisht, Kimya Jones, Vishakha Vashisht, Ravindra Kolhe   +9 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Sorting out Sortilins: structural studies on the VPS10 family [PDF]

, 2017
The topic of this dissertation is the structural characterization of the VPS10 receptors Sortilin and SorCS2, as well as their interactions with proneurotrophins.
Sub Crystal and Structural Chemistry, Crystal and Structural Chemistry, Leloup, N.O.L.   +2 more
core  

Analysis of IL12B gene variants in inflammatory bowel disease [PDF]

, 2012
IL12B encodes the p40 subunit of IL-12, which is also part of IL-23. Recent genome-wide association studies identified IL12B and IL23R as susceptibility genes for inflammatory bowel disease (IBD).
Darina Czamara, Seiderer, J., Seiderer Julia, Ochsenkühn, Thomas, Fries, C., Julia Seiderer (107820), Beigel, F., Wagner, Johanna, Glas, J., Cornelia Tillack (174718), Friedrich, Matthias, Christian Steib (174731), Czamara, D., Diegelmann Julia, Jürgen Glas (107816), Fries Christoph, Tillack, Cornelia, Friedrich Matthias, Steib Christian, Stallhofer, Johannes, Torsten Olszak (107835), Brand, Stephan, Göke, B., Florian Beigel (174724), Brand Stephan, Thomas Ochsenkühn, Olszak Torsten, Beigel, Florian, Matthias Friedrich (174721), Thomas Ochsenkühn (174734), Stallhofer, J., Ochsenkühn, T., Johannes Stallhofer, Matthias Friedrich, Wetzke, M., Darina Czamara (107824), Stephan Brand (107861), Cornelia Tillack, Julia Diegelmann, Beigel Florian, Steib, Christian, Göke, Burkhard, Wetzke Martin, Fries, Christoph, Wagner, J., Friedrich, M., Seiderer, Julia, Glas, Jürgen, Diegelmann, J., Burkhard Göke (109829), Christoph Fries, Ochsenkühn Thomas, Wagner Johanna, Martin Wetzke, Burkhard Göke, Göke Burkhard, Christian Steib, Stephan Brand, Brand, S., Steib, C., Czamara, Darina, Martin Wetzke (107833), Stallhofer Johannes, Julia Diegelmann (107830), Jürgen Glas, Johanna Wagner (174709), Tillack Cornelia, Johanna Wagner, Wetzke, Martin, Czamara Darina, Diegelmann, Julia, Christoph Fries (174714), Johannes Stallhofer (174728), Glas Jürgen, Torsten Olszak, Olszak, T., Florian Beigel, Julia Seiderer, Olszak, Torsten, Tillack, C.   +79 more
core   +2 more sources

Genome-Wide Structural Variation Analysis and Breed Comparison of Local Domestic Ducks in Shandong Province, China

Animals
Structural variations in the duck genome significantly impact the environmental adaptability and phenotypic diversity of duck populations. Characterizing these SVs in local domestic duck breeds from Shandong province offers valuable insights for breed ...
Pengwei Ren, Meixia Zhang, Muhammad Zahoor Khan, Liu Yang, Yadi Jing, Xiang Liu, Xiaohui Yang, Chaoran Zhang, Min Zhang, Zhiming Zhu, Nenzhu Zheng, Lujiao Zhang, Shuer Zhang, Mingxia Zhu   +13 more
doaj   +1 more source

Systematic Identification of Determinants for Single-Strand Annealing-Mediated Deletion Formation in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2017
To ensure genomic integrity, living organisms have evolved diverse molecular processes for sensing and repairing damaged DNA. If improperly repaired, DNA damage can give rise to different types of mutations, an important class of which are genomic ...
Maia Segura-Wang, Megumi Onishi-Seebacher, Adrian M. Stütz, Balca R. Mardin, Jan O. Korbel   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Histone variants--the structure behind the function [PDF]

Briefings in Functional Genomics and Proteomics, 2006
In recent years, the chromatin field has witnessed a renewed interest in histone variants as pertaining to their structural role, but mainly because of the functional specificity they impart to chromatin. In this review, I am going to discuss several of the most recent structural studies on core histone (H2A.Bbd, H2A.Z, H2A.X, macroH2A, H3.3, CENP-A ...
openaire   +2 more sources

Assembly and Analysis of the Complete Mitochondrial Genome of Capsella bursa-pastoris

Plants, 2020
Shepherd’s purse (Capsella bursa-pastoris) is a cosmopolitan annual weed and a promising model plant for studying allopolyploidization in the evolution of angiosperms.
Denis O. Omelchenko, Maxim S. Makarenko, Artem S. Kasianov, Mikhail I. Schelkunov, Maria D. Logacheva, Aleksey A. Penin   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source