Results 61 to 70 of about 908,392 (296)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Echoed induction of nucleotide variants and chromosomal structural variants in cancer cells

Scientific Reports, 2022
AbstractGenerally, the number of single-nucleotide variants (SNVs) in somatic cells increases with age, which is expected for replication errors. The number of SNVs in cancer cells, however, is often much higher than that in somatic cells, raising the question of whether cancer cells possess SNV induction pathways.
Yusuke Matsuno, Rika Kusumoto-Matsuo, Yuya Manaka, Haruka Asai, Ken-ichi Yoshioka   +4 more
openaire   +3 more sources

Assessing Cognitive Functioning in Children With Brain Tumors: Interaction of Neighborhood Social Determinants of Health and Neurological Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background This study investigated how neighborhood‐level social determinants of health (SDOH), including redlining and neurological risk, interact to influence cognitive outcomes in children treated for brain tumors (CTBT). Methods A retrospective chart review of 161 CTBT aged 5–17 was conducted.
Alannah R. Srsich, Manali Zope, Peter M. Fantozzi, Cassie N. Kline, Iris Paltin, Matthew C. Hocking   +5 more
wiley   +1 more source

Assembly and Analysis of the Complete Mitochondrial Genome of Capsella bursa-pastoris

Plants, 2020
Shepherd’s purse (Capsella bursa-pastoris) is a cosmopolitan annual weed and a promising model plant for studying allopolyploidization in the evolution of angiosperms.
Denis O. Omelchenko, Maxim S. Makarenko, Artem S. Kasianov, Mikhail I. Schelkunov, Maria D. Logacheva, Aleksey A. Penin   +5 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Clinical Utility of Optical Genome Mapping for Improved Cytogenomic Analysis of Gliomas

Biomedicines
A glioma is a solid brain tumor which originates in the brain or brain stem area. The diagnosis of gliomas based on standard-of-care (SOC) techniques includes karyotyping, fluorescence in situ hybridization (FISH), and chromosomal microarray (CMA), for ...
Harmanpreet Singh, Nikhil S. Sahajpal, Ashis K. Mondal, Stephanie L. Burke, Jaspreet Farmaha, Ahmet Alptekin, Ashutosh Vashisht, Kimya Jones, Vishakha Vashisht, Ravindra Kolhe   +9 more
doaj   +1 more source

Systematic Identification of Determinants for Single-Strand Annealing-Mediated Deletion Formation in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2017
To ensure genomic integrity, living organisms have evolved diverse molecular processes for sensing and repairing damaged DNA. If improperly repaired, DNA damage can give rise to different types of mutations, an important class of which are genomic ...
Maia Segura-Wang, Megumi Onishi-Seebacher, Adrian M. Stütz, Balca R. Mardin, Jan O. Korbel   +4 more
doaj   +1 more source

Endogeneity in nonparametric and semiparametric regression models [PDF]

, 2001
This paper considers the nonparametric and semiparametric methods for estimating regression models with continuous endogenous regressors. We list a number of different generalizations of the linear structural equation model, and discuss how two common ...
Blundell, R., Powell, J.L.
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Genome-Wide Structural Variation Analysis and Breed Comparison of Local Domestic Ducks in Shandong Province, China

Animals
Structural variations in the duck genome significantly impact the environmental adaptability and phenotypic diversity of duck populations. Characterizing these SVs in local domestic duck breeds from Shandong province offers valuable insights for breed ...
Pengwei Ren, Meixia Zhang, Muhammad Zahoor Khan, Liu Yang, Yadi Jing, Xiang Liu, Xiaohui Yang, Chaoran Zhang, Min Zhang, Zhiming Zhu, Nenzhu Zheng, Lujiao Zhang, Shuer Zhang, Mingxia Zhu   +13 more
doaj   +1 more source