Results 71 to 80 of about 908,392 (296)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Clinical Impact of Molecular Subtyping of Pancreatic Cancer

Frontiers in Cell and Developmental Biology, 2021
Pancreatic ductal adenocarcinoma is a highly lethal malignancy, which has now become the seventh most common cause of cancer death in the world, with the highest mortality rates in Europe and North America.
Xu Zhou, Xu Zhou, Kai Hu, Kai Hu, Peter Bailey, Peter Bailey, Peter Bailey, Christoph Springfeld, Susanne Roth, Roma Kurilov, Benedikt Brors, Benedikt Brors, Thomas Gress, Malte Buchholz, Jingyu An, Jingyu An, Kongyuan Wei, Kongyuan Wei, Teresa Peccerella, Teresa Peccerella, Markus W. Büchler, Thilo Hackert, John P. Neoptolemos, John P. Neoptolemos   +23 more
doaj   +1 more source

The functional analytic foundation of Colombeau algebras [PDF]

, 2013
Colombeau algebras constitute a convenient framework for performing nonlinear operations like multiplication on Schwartz distributions. Many variants and modifications of these algebras exist for various applications.
Nigsch, E. A.
core  

Comprehensive sequence-to-function mapping of cofactor-dependent RNA catalysis in the glmS ribozyme. [PDF]

, 2020
Massively parallel, quantitative measurements of biomolecular activity across sequence space can greatly expand our understanding of RNA sequence-function relationships. We report the development of an RNA-array assay to perform such measurements and its
Andreasson, Johan OL, Block, Steven M, Greenleaf, William J, Savinov, Andrew   +3 more
core  

NiTi shape-memory transformations: minimum-energy pathways between austenite, martensites, and kinetically-limited intermediate states [PDF]

, 2014
NiTi is the most used shape-memory alloy, nonetheless, a lack of understanding remains regarding the associated structures and transitions, including their barriers.
Johnson, Duane, Johnson, Duane, Zarkevich, Nikolai, Zarkevich, Nikolai   +3 more
core   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A Multi-Approach for In Silico Detection of Chromosome Inversions in Mosquito Vectors

Microorganisms
In Brazil, Nyssorhynchus darlingi stands out as the primary malaria vector. Chromosome inversions have long been recognized as critical evolutionary mechanisms in diverse organisms.
Marcus Vinicius Niz Alvarez, Filipe Trindade Bozoni, Diego Peres Alonso, Paulo Eduardo Martins Ribolla   +3 more
doaj   +1 more source

Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO) [PDF]

, 2017
PNPO deficiency is responsible of severe neonatal encephalopathy, responsive to pyridoxal-5’-phosphate (PLP) or pyridoxine. Recent studies widened the phenotype of this condition and detected new genetic variants on PNPO gene, whose pathogenetic role and
Carducci, Carla, Contestabile, Roberto, Di Salvo, Martino L., Guerrini, Renzo, Leuzzi, Vincenzo, Mastrangelo, Mario, Mei, Davide, Montomoli, Martino, Nogués, Isabel, Paiardini, Alessandro, Tolve, Manuela, Tramonti, Angela   +11 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Structural Variants Contribute to Phenotypic Variation in Maize. [PDF]

Mol Ecol
ABSTRACT Comprehensively identifying the loci shaping trait variation has been challenging, in part because standard approaches often miss many types of genetic variants. Structural variants (SVs), especially transposable elements (TEs), are likely to affect phenotypic variation but we lack methods that can detect polymorphic SVs and ...
Catlin NS, Agha HI, Platts AE, Munasinghe M, Hirsch CN, Josephs EB.   +5 more
europepmc   +4 more sources