Results 141 to 150 of about 3,751,240 (350)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

The Analysis of ‘Leading Sectors’: A Long term view of 18 Latin American economies [PDF]

open access: yes
In the 1950s and 60s, in Latin America structuralism was considered as the preeminent form of analysis of economic development and growth. Nowadays, in contrast, as a mode of analysis structuralism is distinctly unfashionable, and has been superceded by ...
Acevedo, Alejandra   +2 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Structural Harm, Structural Injustice, Structural Repair

open access: yes
Abstract In Chapter 1, ‘Structural Harm, Structural Injustice, Structural Repair’, Jonathan Wolff explores the nature of structural injustice and how it tends to come into being. For Wolff, structural harm is not an injustice but rather a mere unfortunate outcome of structural processes.
openaire   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Marxist history and schooling: Beyond economism [PDF]

open access: yes, 1994
Marxist history emphasises the linkage between economic production, social institutions and everyday life. Critics of Marxism claim that its analysis of schooling is simplistic, functional and deterministic The first part of this paper examines whether ...
Down, B.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Teorins pionjärer

open access: yesLychnos, 2009
From the 1970’s onward, comparative literature has held a unique position among the humanities with regard to the reception, development and application of theory.
Michael Gustavsson
doaj  

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