Results 61 to 70 of about 13,823 (308)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Hermeneutics, Structuralism and Post-Structuralism

open access: yes, 2014
A critical essay on the key procedural differentiations between hermeneutics, structuralism and post ...
Davey, Nicholas
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Non-ontological Structuralism†

open access: yes, 2018
Historical structuralist views have been ontological. They either deny that there are any mathematical objects (eliminative structuralism) or they maintain that mathematical objects are structures or positions in them (sui generis structuralism).
Michael Resnik
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

HENRY JAMES’ VIEW ABOUT AMERICAN CULTURE AS REPRESENTED BY DAISY MILLER IN DAISY MILLER (GENETIC STRUCTURALISM APPROACH) [PDF]

open access: yes, 2003
Daisy Miller is one of James’ novels that talks about cultural gap. There are many cultural conflicts between American and European. The researcher had formulated three problem statements as follows: (1) How are the cultural differences in Daisy ...
RIFA’I, HABIB
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Toward a Hermeneutic Categorical Mathematics or why Category theory does not support mathematical structuralism [PDF]

open access: yes, 2006
In this paper I argue that Category theory provides an alternative to Hilbert’s Formal Axiomatic method and doesn't support Mathematical ...
Rodin, Andrei
core  

Structuralism in architecture: a definition

open access: yesJournal of Aesthetics & Culture, 2011
What structuralism in architecture aimed at has often been misunderstood. Structuralism was not about democracy, giving the users of a building the possibility to make changes in it.
Lisbeth Söderqvist
doaj   +1 more source

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