Results 121 to 130 of about 5,429,668 (289)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Giddens’ structuration theory and its implications for management accounting research
, 2009 Structuration theory, Agency, Duality of structure, Routine, Trust,
Busco, C. +2 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
KEKERASAN SEKSUAL TELEVISI TERHADAP WANITA
Jurnal Ilmu Sosial, 2016 The women’s violence issues is found in adult mass media. What kinds of women violence are found in a children’s televisin program in Indonesia. Gender structuration theory guided this research. It used critical discourse analysis.
Sunarto Sunarto
doaj
Giddens’s Structuration Theory and Information Systems Research
, 2008 The work of the contemporary British sociologist Anthony Giddens, and in particular his structuration theory, has been widely cited by Information Systems researchers.
Karsten, Helena, Jones, Matthew R.
core
Studying Human Resource Information Systems Implementation using Adaptive Structuration Theory
, 2011 Research on Human Resource Information Systems (HRIS) implementation lacks theoretical depth and richness. For that reason this paper applies a theory to HRIS implementation developed by Gerardine DeSanctis and Marshal Scott Poole originally for studying
Huub Ruël
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Time and «time/space» concept in Anthony Giddens structuration theory
, 2003 This article analyzes time and «time/space» concepts in A. Giddens Structuration theory. It is argued that while time/space concept can be successfully used in research as separate approach, in the Structuration theory frame it leads to controversies ...
Осипчук, А
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source