Results 121 to 130 of about 5,410,497 (291)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Giddens’ structuration theory and its implications for management accounting research
, 2009 Structuration theory, Agency, Duality of structure, Routine, Trust,
Busco, C. +2 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Giddens’s Structuration Theory and Information Systems Research
, 2008 The work of the contemporary British sociologist Anthony Giddens, and in particular his structuration theory, has been widely cited by Information Systems researchers.
Karsten, Helena, Jones, Matthew R.
core
Studying Human Resource Information Systems Implementation using Adaptive Structuration Theory
, 2011 Research on Human Resource Information Systems (HRIS) implementation lacks theoretical depth and richness. For that reason this paper applies a theory to HRIS implementation developed by Gerardine DeSanctis and Marshal Scott Poole originally for studying
Huub Ruël
core +1 more source
KEKERASAN SEKSUAL TELEVISI TERHADAP WANITA
Jurnal Ilmu Sosial, 2016 The women’s violence issues is found in adult mass media. What kinds of women violence are found in a children’s televisin program in Indonesia. Gender structuration theory guided this research. It used critical discourse analysis.
Sunarto Sunarto
doaj
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Time and «time/space» concept in Anthony Giddens structuration theory
, 2003 This article analyzes time and «time/space» concepts in A. Giddens Structuration theory. It is argued that while time/space concept can be successfully used in research as separate approach, in the Structuration theory frame it leads to controversies ...
Осипчук, А
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source