Results 111 to 120 of about 69,658 (298)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Towards an Archaeology of the Contemporary Past [PDF]
, 2002 Archaeology, defined as the study of material culture, extends from the first preserved human artefacts up to the present day, and in recent years the ‘Archaeology of the Present’ has become a particular focus of research.
Buchli, V
core
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
KEKERASAN SEKSUAL TELEVISI TERHADAP WANITA
Jurnal Ilmu Sosial, 2016 The women’s violence issues is found in adult mass media. What kinds of women violence are found in a children’s televisin program in Indonesia. Gender structuration theory guided this research. It used critical discourse analysis.
Sunarto Sunarto
doaj
Politeness and face in digitally reconfigured e-learning spaces [PDF]
, 2006 This paper has two starting points. The first is a theorization about the way in which “rhetorical space” is reshaped in asynchronous, online, learning environments.
Daly, Nicola, Locke, Terry
core +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
The Transposition of Power: Law, Lawyers and Social Movements [PDF]
, 2017 Various groups of people have been the victims of oppression throughout time and across national borders and cultures. Many forms of oppression continue to exist all over the world today, including in the United States. I have been particularly concerned
Diamond, Michael R.
core +1 more source
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
The emergence of information systems: a communication-based theory [PDF]
, 2010 An information system is more than just the information technology; it is the system that emerges from the complex interactions and relationships between the information technology and the organization.
Holten, Roland, Rosenkranz, Christoph
core +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source