Results 111 to 120 of about 7,023 (306)

Sundanese Women in Politics: A Structural Analysis to Inform Educational Strategies for Gender Equality

open access: yesCakrawala Pendidikan: Jurnal Ilmiah Pendidikan
This study examines Sundanese women's participation in legislative institutions through a structuration theory approach to inform educational strategies for gender equality.
Siti Komariah   +2 more
doaj   +1 more source

Conceptualizing Interaction with ERP Systems Using Adaptive Structuration Theory

open access: yes, 2007
The new brand of Information Systems (IS) is Enterprise Resource Planning (ERP) and while lots of studies have used functional and networking type IS to operationalize adoption (or system usage) measures, ERP systems have yet to mature in that area ...
Tan, Felix, Sedera, Darshana
core  

Studying Human Resource Information Systems Implementation using Adaptive Structuration Theory

open access: yes, 2009
Research on Human Resource Information Systems (HRIS) implementation lacks theoretical depth and richness. For that reason this paper applies a theory to HRIS implementation developed by Gerardine DeSanctis and Marshal Scott Poole originally for studying
Ruel H., Huub Ruël
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Giddens’s Structuration Theory and Information Systems Research

open access: yes, 2008
The work of the contemporary British sociologist Anthony Giddens, and in particular his structuration theory, has been widely cited by Information Systems researchers.
Karsten, Helena, Jones, Matthew R.
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

STRUCTURATION THEORY AND INFORMATION SYSTEMS RESEARCH

open access: yes, 1990
Research on the social and organizational aspects of information systems often lacks an adequate theoretical and methodological basis. In this paper, we propose that structuration theory provides a broad conception of social action and human society ...
Walsham, Geoff, Han, Chun-Kwong
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Time and «time/space» concept in Anthony Giddens structuration theory

open access: yes, 2003
This article analyzes time and «time/space» concepts in A. Giddens Structuration theory. It is argued that while time/space concept can be successfully used in research as separate approach, in the Structuration theory frame it leads to controversies ...
Осипчук, А
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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