Results 61 to 70 of about 7,023 (306)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
"This does my head in". Ethnographic study of self-management by people with diabetes
BMC Health Services Research, 2012 Background Self-management is rarely studied 'in the wild'. We sought to produce a richer understanding of how people live with diabetes and why self-management is challenging for some.
Hinder Susan, Greenhalgh Trisha
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
, 2002 This chapter argues that the three most commonly used perspectives in conducting research on business-to-business (B2B) eCommerce-transaction cost economics, electronic market hypothesis, and network analysis-have inadequately explained the unfolding ...
Pavlou, Paul A. +3 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
STS: a structural theory of sets [PDF]
Logic Journal of IGPL, 1999 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +6 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Structured learning modulo theories
Artificial Intelligence, 2017 Modelling problems containing a mixture of Boolean and numerical variables is a long-standing interest of Artificial Intelligence. However, performing inference and learning in hybrid domains is a particularly daunting task. The ability to model this kind of domains is crucial in "learning to design" tasks, that is, learning applications where the goal
Teso, Stefano +2 more
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Operational theories as structural realism
Studies in History and Philosophy of Science, 2022 We undertake a reconstruction of the epistemic significance of research on operational theories in quantum foundations. We suggest that the space of operational theories is analogous to the space of possible worlds employed in the possible world semantics for modal logic, so research of this sort can be understood as probing modal structure.
openaire +4 more sources