Results 141 to 150 of about 10,109,694 (374)
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics
MedComm – OncologyJanus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited therapeutic benefits due to their lack of selectivity.
Tian‐Hua Wei +18 more
doaj +1 more source
Mining Essential Relationships under Multiplex Networks [PDF]
arXiv, 2015 In big data times, massive datasets often carry different relationships among the same group of nodes, analyzing on these heterogeneous relationships may give us a window to peek the essential relationships among nodes. In this paper, first of all we propose a new metric "similarity rate" in order to capture the changing rate of similarities between ...
arxiv
Quantile Regression Neural Networks Based Prediction of Drug Activities [PDF]
, 2014 QSAR (quantitative structure-activity relationship) modeling is one of the well developed areas in drug development through computational chemistry. Similar molecules with just a slight variation in their structure can have quit different biological ...
El-Telbany, Mohammed E.
core +2 more sources
Molecular Oncology, EarlyView.Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda +3 more
wiley +1 more source
Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex
Journal of Future FoodsGlycoprotein complexes, a kind of structural biomolecules, are characterized by extensive functions, such as immunomodulatory and anti-inflammatory activities.
Yu Zhong +7 more
doaj
Chemistry Central Journal, 2017 Background A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3a–t was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the appropriate aromatic amine.
Mostafa M. Ghorab +5 more
doaj +1 more source
Pattern recognition system based on support vector machines: HIV-1 integrase inhibitors application [PDF]
, 2013 Support Vector Machines (SVM) represent one of the most promising Machine Learning (ML) tools that can be applied to develop a predictive Quantitative Structure-Activity Relationship (QSAR) models using molecular descriptors.
Darnag, Rachid +2 more
core +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Molecules, 2014 As part of our continuing research on isoquinoline acaricidal drugs, this paper reports the preparation of a series of the 2-aryl-1-cyano-1,2,3,4-tetrahydroisoquinolines with various substituents on the N-phenyl ring, their in vitro acaricidal activities
Rui Yang +6 more
doaj +1 more source