Results 151 to 160 of about 1,492,525 (254)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Quantitative Structure–Activity Relationship

Quantitative Structure–Activity Relationship (QSAR), or Hubungan Kuantitatif Struktur dan Aktivitas (HKSA), is a computational approach in medicinal chemistry used to understand the relationship between the chemical structure of compounds and their ...
Vioni Yulianti
core  

Structure-activity relationship (SAR) in monosaccharide-based Toll-like receptor 4 (TLR4) antagonists

, 2018
The structure-activity relationship was investigated in a series of synthetic TLR4 antagonists formed by a glucosamine core linked to two phosphate esters and two linear carbon chains.
Andra Schromm (4951483), Roman Jerala (165758), Cristina Airoldi (204048), Grisha Pirianov (4951486), Charys Palmer (4951480), Matilde Forcella (401670), Carlotta Ciaramelli (3192903), Alberto Minotti (4951495), Sonsoles Martin-Santamaria (2727910), Francesco Peri (178749), Jean-Marc Billod (3073041), Harald Braun (4951489), Valentina Calabrese (1720351), Paola Fusi (401672), Rudi Beyaert (9500), Silvia Rapisarda (4951498), Fabio A Facchini (10663677), Lenny Zaffaroni (4951477)   +17 more
core  

Structure-Activity Relationship of Cyanine Dyes in Relation to the Hepatic Uptake and Excretion. [PDF]

Chembiochem
Berehova NS, de Bock ELJ, van Meerbeek MP, Naar CM, van den Eng T, Bouw NA, Buckle T, van Leeuwen FWB.   +7 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Structure-Activity Relationship and Crystallographic Study of New Monobactams. [PDF]

J Med Chem
Kavaš V, Contreras-Martel C, Pajk S, Knez D, Martins A, Gould TA, Roper DI, Zdovc I, Dessen A, Hrast Rambaher M, Gobec S.   +10 more
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Affinity-based Structure-Activity-Relationship Models: Improving Structure-Activity-Relationship Models by Incorporating Activity Information from Related Targets

, 2009
Structure-activity-relationship SAR models are used to inform and guide the iterative optimization of chemical leads, and play a fundamental role in modern drug discovery.
Karypis, George, Ning, Xia, Rangwala, Huzefa   +2 more
core  

P-Selectin Inhibition and the Structure-Activity Relationship of Sea Cucumber-Derived Fucosylated Glycosaminoglycan Oligosaccharides. [PDF]

Mar Drugs
Li S, Lin L, Yang L, Pan Y, Gao N, Yin R, Zeng C, Zhao J.   +7 more
europepmc   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source