Results 1 to 10 of about 1,019,415 (265)
Modeling Structure–Activity Relationship of AMPK Activation [PDF]
Molecules, 2021 The adenosine monophosphate activated protein kinase (AMPK) is critical in the regulation of important cellular functions such as lipid, glucose, and protein metabolism; mitochondrial biogenesis and autophagy; and cellular growth. In many diseases—such as metabolic syndrome, obesity, diabetes, and also cancer—activation of AMPK is beneficial. Therefore,
Jürgen Drewe +5 more
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Structure-activity relationships of the nikkomycins [PDF]
Journal of General Microbiology, 1991 The structure-activity relationships of different nikkomycins were studied to evaluate the structural requirements for a potent chitin synthase inhibitor. We investigated the transport of the nikkomycins via the peptide transport system of the yeast Yarrowia lipolytica and determined the kinetic parameters for nikkomycin Z uptake [Km = 24 microM, Vmax =
H, Decker +4 more
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QnrS1 structure-activity relationships [PDF]
Journal of Antimicrobial Chemotherapy, 2014 Loop B is important for low-level quinolone resistance conferred by Qnr proteins. The role of individual amino acids within QnrS1 loop B in quinolone resistance and gyrase protection was assessed.qnrS1 and 11 qnrS1 alleles with site-directed Ala mutations in loop B were expressed in Escherichia coli BL21(DE3) and proteins were purified by affinity ...
Tavío, María M. +2 more
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Structure-Activity Relationship in NOD2 Agonistic Muramyl Dipeptides
, 2023 Nucleotide-binding oligomerization domain 2 (NOD2) is a receptor of the innate immune system that is capable of perceiving bacterial and viral infections.
Aarzoo, Kamboj +3 more
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Electrochemical behavior of indolone-N-oxides: Relationship to structure and antiplasmodial activity [PDF]
, 2012 Indolone-N-oxides exert high parasiticidal activity at the nanomolar level in vitro against Plasmodiumfalciparum, the parasite responsible for malaria.
Perio, Pierre +6 more
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Structure-Activity Relationship of Mutant KatG from INH resistant Mycobacterium tuberculosis [PDF]
, 2017 Mutation in katG gene of Mycobacterium tuberculosis encoding catalase-peroxidase that damage its enzyme activities is well associated with isoniazid (INH) resistance. The katG gene from INH resistant strain of M.
Purkan +4 more
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Structure-Activity Relationship and Bioactivity Studies of Neurotrophic trans-Banglene
, 2021 Neurotrophic small molecule natural products are functional analogs of signaling proteins called neurotrophins, which cause a pro-growth, pro-survival, or pro-differentiation response in neuronal cells.
Khyati, Gohil +2 more
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Structure-activity relationships of estrogens.
Environmental Health Perspectives, 1985 The last 50 years has seen an exponential rise in the published reports about estrogen action. The model to describe the early events in the mechanism of action of estrogens via the estrogen receptor is updated in this paper to incorporate some of the recent data on the subcellular localization of the receptor.
V C, Jordan +4 more
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, 2023 Monoacylglyerol lipase (MAGL) is the key enzyme for the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-AG). The central role of MAGL in the metabolism of 2-AG makes it an attractive therapeutic target for a variety of disorders, including ...
Renze, Bakker +9 more
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Synthesis and leishmanicidal activity of cinnamic acid esters: structure–activity relationship [PDF]
, 2014 Several cinnamic acid esters were obtained via Fischer esterification of cinnamic acids derivatives with aliphatic alcohols. Structures of the products were elucidated by spectroscopic analysis.
Vélez, Iván D. +8 more
core +1 more source