Results 41 to 50 of about 16,673,842 (253)

Synthesis and Structure-Activity Relationship Studies of C(13)-Desmethylene-(−)-Zampanolide Analogs [PDF]

, 2023
We have prepared a series of partially reduced or demethylated analogs of the natural microtubule stabilizer (−)-zampanolide and we have assessed their antiproliferative activity, their microtubule-binding affinity and their effects on the cellular ...
Simone, Berardozzi, Bernhard, Pfeiffer, John H., Miller, Sandro, Pagani, Mariano, Redondo-Horcajo, J. Fernando, Díaz, Daniel, Lucena-Agell, Karl-Heinz, Altmann, Tobias Michael, Brütsch, Etienne, Cotter, Carolina, Davies   +10 more
core   +1 more source

Synthesis, antimicrobial screening and structure–activity relationship of novel pyrimidines and their thioethers

Bulletin of Faculty of Pharmacy Cairo University, 2014
In the present study, a series of novel pyrimidines (1) and their thioethers (2–5) were synthesized. Structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR mass spectral data and elemental analysis.
Chetan M. Bhalgat, B. Ramesh
doaj   +1 more source

Flavonoids as inhibitors of human neutrophil elastase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Elastase is a proteolytic enzyme belonging to the family of hydrolases produced by human neutrophils, monocytes, macrophages, and endothelial cells.
Katarzyna Jakimiuk, Jakub Gesek, Atanas G. Atanasov, Michał Tomczyk   +3 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Anticancer activity of natural cytokinins: a structure-activity relationship study

, 2010
Cytokinin ribosides (N(6)-substituted adenosine derivatives) have been shown to have anticancer activity both in vitro and in vivo. This study presents the first systematic analysis of the relationship between the chemical structure of cytokinins and ...
Dolezal, Karel, Krystof, Vladimír, Lenobel, René, Hajdúch, Marián, Dzubák, Petr, Strnad, Miroslav, Spíchal, Lukás, Niemann, Percy, Zatloukal, Marek, Voller, Jirí, Béres, Tibor   +10 more
core   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Quantitative Structure–Activity Relationship

Quantitative Structure–Activity Relationship (QSAR), or Hubungan Kuantitatif Struktur dan Aktivitas (HKSA), is a computational approach in medicinal chemistry used to understand the relationship between the chemical structure of compounds and their ...
Vioni Yulianti
core   +7 more sources

Research Progress on Structure, Activity and Structure-Activity Relationship of Sea Cucumber Polysaccharides [PDF]

Shipin Kexue
The sea cucumber is an invertebrate with significant economic value and is extensively consumed as a tonic food in Asian countries due to its high nutritional value.
SHU Zhiqiang, LIU Fang, JING Yuexin, JIAO Chunna, JI Yizhi, WANG Maojian, WANG Gongming, ZHANG Jian
doaj   +1 more source

Provider and Parent Perspectives on Prioritizing the “Asking and Monitoring” Pediatric Cancer Psychosocial Standards of Care

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families (“Standards”) are evidence‐based guidelines for psychosocial care in pediatric oncology. Care related to the three “Asking and Monitoring” Standards—Assessment of Psychosocial Needs, Assessment of Financial Needs, and Monitoring Neurocognitive Problems ...
Julia B. Tager, Natalie Koskela‐Staples, Emily M. Pariseau, Michele Scialla, Kimberly Buff, Lori Wiener, Victoria Sardi Brown, Anne E. Kazak, Kimberly S. Canter   +8 more
wiley   +1 more source

Anticancer Activities of Polyynes from the Root Bark of Oplopanax horridus and Their Acetylated Derivatives

Molecules, 2014
Six polyynes OH-1~6, some of which are occur naturally in acetylated form, had been isolated and identified from the root bark of Oplopanax horridus (Devil’s Club), a natural dietary supplement and medicinal plant in North America.
Wei-Hua Huang, Li Shao, Chong-Zhi Wang, Chun-Su Yuan, Hong-Hao Zhou   +4 more
doaj   +1 more source