Results 51 to 60 of about 1,019,415 (265)

Structure activity relationship of IWR compounds.

, 2012
Structure activity relationship of IWR compounds.
Xin Huang (11077), Hakan Gunaydin (177019), Yan Gu (125500)   +2 more
core   +1 more source

TDPBP Derivative Aiding Liquid-Phase Synthesis Strategy and ACE Inhibitory Structure-activity Relationship of Anti-SARS Octapeptide

, 2020
The tri(4\u27-diphenylphosphonyloxylbenzoyl phenyl) phosphate (TDPBP) derivatives were designed and developed as C-terminal supports to aid the greener and highefficient liquid-phase peptide synthesis (LPPS) without the need of unrecyclable resin and ...
Haidi, Li, Zixin, Zhang, Ninghui, Chang, Chuanguang, Qin, Jin, Ren, Junyou, Li   +5 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Metabolic profile and structure–activity relationship of resveratrol and its analogs in human bladder cancer cells

, 2019
Yang Yang,1,2 Guangyuan Zhang,2 Chuangang Li,3 Sihan Wang,2 Manning Zhu,2 Jinan Wang,2 Hangtian Yue,2 Xiaodong Ma,2 Yuhong Zhen,2 Xiaohong Shu1,21College of Integrative Medicine, Dalian Medical University, Dalian 116044, People’s Republic of China;
Zhang G, Zhu M, Yang Y, Li C, Wang S, Ma X, Shu X, Wang J, Yue H, Zhen Y   +9 more
core  

Styrylchromones: Biological Activities and Structure‐Activity Relationship

ChemMedChem
AbstractStyrylchromones (SC) are a group of oxygen‐containing heterocyclic compounds, which are characterized by the attachment of a styryl group to the chromone core. SC can be found in nature or can be chemically synthesized in the laboratory. As their presence in nature is scarce, the synthetic origin is the most common. Two types of SC are known: 2‐
Mariana Lucas, Marisa Freitas, Artur M. S. Silva, Eduarda Fernandes, Daniela Ribeiro   +4 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Synthesis and Structure-Activity Relationship Studies of Dioxane- and Oxathiane-Based Analogs of (–)-Zampanolide

We have prepared a series of analogs of the complex marine macrolide (–)-zampanolide, which incorporate a dioxane-, oxathiane-, or oxathiane-dioxide ring in place of the natural tetrahydropyran moiety and we have determined their microtubule-binding ...
Simon, Glauser, Plinio, Scapozza, Simone, Berardozzi, Rafael, Hortigüela, Alina, Lelke, J. Fernando, Díaz, Daniel, Lucena-Agell, Maria, Oliva, Karl-Heinz, Altmann, Etienne, Cotter   +9 more
core   +1 more source

Physical activity and depressive symptoms in adolescents: a prospective study [PDF]

, 2010
Background: The frequency of mental illness amongst adolescents and its potential long-term consequences make it an important topic to research in relation to risk and protective factors.
Viner Russell M, Stansfeld, SA, Stephen A Stansfeld, Kamaldeep Bhui, Viner, Russell M, Russell M Viner, Rothon, Catherine, Edwards Phil, Taylor, S, Edwards, P, Bhui, K, Bhui Kamaldeep, Taylor, Stephanie, Rothon Catherine, Stansfeld Stephen A, Viner, RM, Phil Edwards, Catherine Rothon, Bhui, Kamaldeep, Taylor Stephanie, Stansfeld, Stephen A, Edwards, Phil, Rothon, C, Stephanie Taylor   +23 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases

, 2019
1. We investigated the structure-activity relationship of 31 kinds of synthesized atorvastatin esters, thioesters, amides and lactone, selected as prodrug models, for metabolic activation by microsomes and hydrolases. 2.
Takuo Ogihara (568142), Masato Takahashi (81701), Masakiyo Hosokawa (5149124), Kenta Mizoi (6856832), Masami Haba (6856838), Sachiko Sakai (6856835)   +5 more
core   +1 more source