Results 31 to 40 of about 16,673,842 (253)

Structure-Activity Relationships of Adrenocorticoids

Experimental Biology and Medicine, 1961
SummaryThe influence of 1,2 unsaturation, 6a-methylation, 9a-fluorination, 16a-hydroxylation, and 16a,17a-ketalization alone and in combination on glycogenic and thymolytic activity has been simultaneously assessed in immature adrenalectomized rats. Good agreement between glycogenic and thymolytic relative potencies was observed.
I, RINGLER, S, MAUER, E, HEYDER
openaire   +2 more sources

Structure Features of Peptide-Type SARS-CoV Main Protease Inhibitors: Quantitative Structure Activity Relationship Study [PDF]

, 2020
In the present work, an extensive QSAR (Quantitative Structure Activity Relationships) analysis of a series of peptide-type SARS-CoV main protease (MPro) inhibitors following the OECD guidelines has been accomplished.
Vesna, Rastija, Meghshyam K., Patil, Ajaykumar, Gandhi, Vijay, Masand   +3 more
core   +1 more source

An Insight into Antihyperlipidemic Effects of Polysaccharides from Natural Resources

Molecules, 2022
Hyperlipidemia is a chronic metabolic disease caused by the abnormal metabolism of lipoproteins in the human body. Its main hazard is to accelerate systemic atherosclerosis, which causes cerebrovascular diseases such as coronary heart disease and ...
Yong-Shuai Jing, Yun-Feng Ma, Fei-Bing Pan, Ming-Song Li, Yu-Guang Zheng, Lan-Fang Wu, Dan-Shen Zhang   +6 more
doaj   +1 more source

Improvement of the Oxidative Stability of Rosehip, Hemp, and Passion Fruit Oils by the Addition of Monocyclic Phenols as Antioxidants

Antioxidants
Caffeic, syringic, and protocatechuic acids are phenolic acids with important antioxidant activity. In this work we studied how the oxidative stability of rosehip, hemp, and passion fruit oils improves with the addition of these antioxidant acids.
Gloria Castellano, Irene Sarrión, Carmen Fagoaga, Ricardo M. Giménez-Núñez, Enrique Gómez-Gómez, Francisco Torrens   +5 more
doaj   +1 more source

Pyrimidine: a review on anticancer activity with key emphasis on SAR

Future Journal of Pharmaceutical Sciences, 2021
Background Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents.
Aastha Mahapatra, Tanya Prasad, Tripti Sharma   +2 more
doaj   +1 more source

Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP

Drug Design, Development and Therapy, 2022
Lijing Wang College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Lijing Wang, College of Life Science and Technology, China Pharmaceutical University, 639 Longmian ...
Wang L
doaj  

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Inflammation and disease are closely related. Inflammation can induce various diseases, and diseases can promote inflammatory response, and two possibly induces each other in a bidirectional loop.
Ming Bian, Qian-qian Ma, Yun Wu, Huan-huan Du, Gong Guo-hua   +4 more
doaj   +1 more source

Semi-Synthesis of Harringtonolide Derivatives and Their Antiproliferative Activity

Molecules, 2021
Harringtonolide (HO), a natural product isolated from Cephalotaxus harringtonia, exhibits potent antiproliferative activity. However, little information has been reported on the systematic structure−activity relationship (SAR) of HO derivatives ...
Xiutao Wu, Lijie Gong, Chen Chen, Ye Tao, Wuxi Zhou, Lingyi Kong, Jianguang Luo   +6 more
doaj   +1 more source

Expedient Synthesis of a Library of Heparan Sulfate Like “Head to Tail” Linked Multimers for Structure and Activity Relationship Studies [PDF]

, 2022
Heparan sulfate (HS) plays significant roles in various biological processes such as inflammation, cell proliferation, and bacterial and viral infection. The inherent complexity of naturally existing HS has severely hindered the thorough understanding of
Chang-xin, Huo, Fuming, Zhang, Kedar, Baryal, Linda, Hsieh-wilson, Li, Liang, Weizhun, Yang, Jian, Liu, Xuefei, Huang, Jicheng, Zhang, Robert, Linhardt, Sherif, Ramadan, Jamie, Bernard   +11 more
core   +1 more source

Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex

Journal of Future Foods
Glycoprotein complexes, a kind of structural biomolecules, are characterized by extensive functions, such as immunomodulatory and anti-inflammatory activities.
Yu Zhong, Jiangxiong Zhu, Bifen Zhu, Hao Yin, Danfeng Wang, Yun Deng, Minyan Zhang, Chunrong Zhang   +7 more
doaj   +1 more source