Results 11 to 20 of about 1,019,415 (265)

Quantitative Structure Activity Relationship (QSAR) study predicts small molecule binding to RNA structure

, 2021
The diversity of RNA structural elements and their documented role in human diseases make RNA an attractive therapeutic target. However, progress in drug discovery and development has been hindered by challenges in the determination of high-resolution ...
Martina, Zafferani, Zhengguo, Cai, Amanda, Hargrove, Olanrewaju, Akande   +3 more
core   +1 more source

Antioxidant activity of taxifolin: an activity–structure relationship [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015
Taxifolin is a kind of flavanonol, whose biological ability. The objectives of this study were to investigate the antioxidants and antiradical activities of taxifolin by using different in vitro bioanalytical antioxidant methods including DMPD√(+), ABTS√(+), [Formula: see text], and DPPH√-scavenging effects, the total antioxidant influence, reducing ...
Topal, Fevzi, Nar, Meryem, Gocer, Hulya, Kalin, Pinar, Kocyigit, Umit M., Gulcin, Ilhami, Alwasel, Saleh H.   +6 more
openaire   +4 more sources

Comprehensive Structure-Activity Relationship Studies of Cepafungin Enabled by Biocatalytic C–H Oxidations

, 2022
The cepafungins are a class of highly potent and selective eukaryotic proteasome inhibitor natural products with potential to treat refractory multiple myeloma and other cancers.
Hans, Renata, Anton, Shuster, Alexander, Amatuni, Alexander, Adibekian, Daniel, Abegg   +4 more
core   +1 more source

Structure-Activity Relationships of Adrenocorticoids

Experimental Biology and Medicine, 1961
SummaryThe influence of 1,2 unsaturation, 6a-methylation, 9a-fluorination, 16a-hydroxylation, and 16a,17a-ketalization alone and in combination on glycogenic and thymolytic activity has been simultaneously assessed in immature adrenalectomized rats. Good agreement between glycogenic and thymolytic relative potencies was observed.
I, RINGLER, S, MAUER, E, HEYDER
openaire   +2 more sources

Synthesis and Structure-Activity Relationship Studies of C(13)-Desmethylene-(−)-Zampanolide Analogs

, 2023
We have prepared a series of partially reduced or demethylated analogs of the natural microtubule stabilizer (−)-zampanolide and we have assessed their antiproliferative activity, their microtubule-binding affinity and their effects on the cellular ...
Simone, Berardozzi, Bernhard, Pfeiffer, John H., Miller, Sandro, Pagani, Mariano, Redondo-Horcajo, J. Fernando, Díaz, Daniel, Lucena-Agell, Karl-Heinz, Altmann, Tobias Michael, Brütsch, Etienne, Cotter, Carolina, Davies   +10 more
core   +1 more source

Expedient Synthesis of a Library of Heparan Sulfate Like “Head to Tail” Linked Multimers for Structure and Activity Relationship Studies

, 2022
Heparan sulfate (HS) plays significant roles in various biological processes such as inflammation, cell proliferation, and bacterial and viral infection. The inherent complexity of naturally existing HS has severely hindered the thorough understanding of
Chang-xin, Huo, Fuming, Zhang, Kedar, Baryal, Linda, Hsieh-wilson, Li, Liang, Weizhun, Yang, Jian, Liu, Xuefei, Huang, Jicheng, Zhang, Robert, Linhardt, Sherif, Ramadan, Jamie, Bernard   +11 more
core   +1 more source

Anticancer activity of natural cytokinins: a structure-activity relationship study

, 2010
Cytokinin ribosides (N(6)-substituted adenosine derivatives) have been shown to have anticancer activity both in vitro and in vivo. This study presents the first systematic analysis of the relationship between the chemical structure of cytokinins and ...
Dolezal, Karel, Krystof, Vladimír, Lenobel, René, Hajdúch, Marián, Dzubák, Petr, Strnad, Miroslav, Spíchal, Lukás, Niemann, Percy, Zatloukal, Marek, Voller, Jirí, Béres, Tibor   +10 more
core   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source