Structure - Activity Relationship of Mutant KatG from INH resistant Mycobacterium tuberculosis [PDF]
Journal of Pure and Applied Microbiology, 2017 Mutation in katG gene of Mycobacterium tuberculosis encoding catalase-peroxidase that damage its enzyme activities is well associated with isoniazid (INH) resistance. The katG gene from INH resistant strain of M.
Purkan Purkan +4 more
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Drug Design, Development and Therapy, 2018 Isnatin Miladiyah,1,2 Jumina Jumina,3 Sofia Mubarika Haryana,4 Mustofa Mustofa5 1Pharmacology Department, Faculty of Medicine, Islamic University of Indonesia, 2Doctorate Program of Medical Science and Health, Faculty of Medicine, 3Chemistry Department,
Miladiyah I +3 more
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Cancer Management and Research, 2019 Yang Yang,1,2 Guangyuan Zhang,2 Chuangang Li,3 Sihan Wang,2 Manning Zhu,2 Jinan Wang,2 Hangtian Yue,2 Xiaodong Ma,2 Yuhong Zhen,2 Xiaohong Shu1,21College of Integrative Medicine, Dalian Medical University, Dalian 116044, People’s Republic of China;
Yang Y +9 more
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Structure-Activity Relationship in NOD2 Agonistic Muramyl Dipeptides [PDF]
, 2023 Nucleotide-binding oligomerization domain 2 (NOD2) is a receptor of the innate immune system that is capable of perceiving bacterial and viral infections.
Aarzoo, Kamboj +3 more
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Structure-Activity Relationship and Bioactivity Studies of Neurotrophic trans-Banglene [PDF]
, 2021 Neurotrophic small molecule natural products are functional analogs of signaling proteins called neurotrophins, which cause a pro-growth, pro-survival, or pro-differentiation response in neuronal cells.
Khyati, Gohil +2 more
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Structure-activity relationship studies of arylsulfoxides as reversible monoacylglycerol lipase inhibitors [PDF]
, 2023 Monoacylglyerol lipase (MAGL) is the key enzyme for the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-AG). The central role of MAGL in the metabolism of 2-AG makes it an attractive therapeutic target for a variety of disorders, including ...
Renze, Bakker +9 more
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Quantitative Structure Activity Relationship (QSAR) study predicts small molecule binding to RNA structure [PDF]
, 2021 The diversity of RNA structural elements and their documented role in human diseases make RNA an attractive therapeutic target. However, progress in drug discovery and development has been hindered by challenges in the determination of high-resolution ...
Martina, Zafferani +3 more
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Electrochemical behavior of indolone-N-oxides: Relationship to structure and antiplasmodial activity [PDF]
, 2012 Indolone-N-oxides exert high parasiticidal activity at the nanomolar level in vitro against Plasmodiumfalciparum, the parasite responsible for malaria.
Perio, Pierre +6 more
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Comprehensive Structure-Activity Relationship Studies of Cepafungin Enabled by Biocatalytic C–H Oxidations [PDF]
, 2022 The cepafungins are a class of highly potent and selective eukaryotic proteasome inhibitor natural products with potential to treat refractory multiple myeloma and other cancers.
Hans, Renata +4 more
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Structure-activity relationships of 3-substituted-5,5- diphenylhydantoins as potential antiproliferative and antimicrobial agents [PDF]
Journal of the Serbian Chemical Society, 2011 A series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature.
Trišović Nemanja +7 more
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