Results 211 to 220 of about 10,109,694 (374)
Inhibition of RNA polymerase and formyltetrahydrofolate synthetase activity by 6‐chloro‐8‐aza‐9‐cyclopentylpurine. Structure‐activity relationships [PDF]
, 1970 Raymond W. Ruddon +2 more
openalex +1 more source
Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang +16 more
wiley +1 more source
STRUCTURE-BIOLOGICAL ACTIVITIES RELATIONSHIPS AMONG LEUCOMYCINS AND THEIR DERIVATIVES
, 1968 Satoshi Ōmura +7 more
openalex +2 more sources
Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapies, and surgical interventions, their limitations necessitate exploring novel therapeutic ...
Ahmed Y. Azzam +13 more
wiley +1 more source
A STUDY ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF THE CARDIOTONIC STEROIDS
, 1965 Shoichi Imai +4 more
openalex +1 more source
Skin calcium deposits in primary familial brain calcification: A novel potential biomarker
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Primary Familial Brain Calcification (PFBC) is a rare neurodegenerative disorder characterized by small vessel calcifications in the basal ganglia. PFBC is caused by pathogenic variants in different genes and its physiopathology is still largely unknown. Skin vascular calcifications have been detected in single PFBC cases, suggesting
Aron Emmi +8 more
wiley +1 more source
An MRI assessment of mechanisms underlying lesion growth and shrinkage in multiple sclerosis
Annals of Clinical and Translational Neurology, EarlyView.By applying the tensor model, we analysed lesion orientation and the directionality of lesion expansion/contraction in multiple sclerosis. Each lesion is summarized as an ellipsoid, and the tensor model is applied to calculate lesion anisotropy. From the top to the bottom white matter atlas, surface‐in gradient segmentation and venous atlas used in the
Ermelinda De Meo +9 more
wiley +1 more source