Results 231 to 240 of about 17,685,797 (244)

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Identification and structure-activity relationship studies of clavatol as an antifungal compound against pathogenic plant fungi using a drug-hypersensitive fission yeast screening system. [PDF]

J Pestic Sci
Kimishima A, Negami S, Yoda W, Kamo T, Honma S, Kawashima SA, Yashiroda Y, Wasuwanich P, Ujie Y, Fuji SI, Tokiwa T, Kojima H, Sugawara A, Chinen T, Usui T, Asami Y.   +15 more
europepmc   +1 more source

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source

A comprehensive review on chemical structure, quality control, pharmacological effects, and structure-activity relationship of saponins from Zhuzishen (). [PDF]

J Tradit Chin Med
Zeting M, Qianqian XU, Mengqiong S, Wei G, Jihong Z, Maohua C, Jie XU, Huiquan HU, Gang Z, Haiming T.   +9 more
europepmc   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Anti-Inflammatory Potential of 1-Aryl-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinolines: Structure-Activity Relationship and COX-2 Binding. [PDF]

Molecules
Azamatov AA, Tursunkhodzhaeva FM, Zhurakulov SN, Boboev ZD, Kuchimov KF, Aytmuratova UK, Ortikov IS, Abdurazakova RS, Vinogradova VI, Abdullaev IZ, Gayibov UG.   +10 more
europepmc   +1 more source

Molecular Docking and Structure-Activity Relationship Study of Polyphenols with Antibacterial and Antibiotic-Modulating Properties. [PDF]

Microorganisms
Trabsa H, Krache I, Boussoualim N, Kara A, Saouli N, Raish M, Jeon BH, Ahn HJ, Benguerba Y.   +8 more
europepmc   +1 more source

Structure-Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers. [PDF]

J Med Chem
Errico S, Bigi A, Fani G, Ambrosino M, Galmiche E, Bemporad F, Vendruscolo M, Mannini B, Chiti F.   +8 more
europepmc   +1 more source

Structure-Activity Relationship Evaluation of Melatonin and Its Derivatives for Wound-Healing Applications: A Combined Network Pharmacology, Molecular Docking, and Biological Validation Approach. [PDF]

Int J Mol Sci
Siriparu P, Sungthong B, Puthongking P.
europepmc   +1 more source

Structural evolution of quinine derivatives for enhanced antifungal potency: key modifications and quantitative structure-activity relationship (QSAR) analysis. [PDF]

Pest Manag Sci
Fan L, Wu Y, Lei Y, Liu Y, Li M, Chen C, Zhang H, Shi L, Peng J.   +8 more
europepmc   +1 more source