Results 61 to 70 of about 10,109,694 (374)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Longitudinal predictors of weapon involvement in middle adolescence: Evidence from the UK Millennium Cohort Study

Aggressive Behavior, Volume 49, Issue 1, Page 5-14, January 2023., 2023
Abstract This study uses longitudinal data from the UK Millennium Cohort Study (N = 13,277) to examine the childhood and early adolescence factors that predict weapon involvement in middle adolescence, which in this study is exemplified by having carried or used a weapon.
Aase Villadsen, Emla Fitzsimons
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5

Molecules, 2020
Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases. They regulate many physiological processes and play important roles in inflammation, diabetes, cancers, and neurodegeneration diseases.
Haozhen Han, Chunpu Li, Man Li, Lisheng Yang, Sen Zhao, Zhifei Wang, Hong Liu, Dongxiang Liu   +7 more
doaj   +1 more source

MOESM1 of 4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structureâ activity relationship studies

, 2018
Additional file 1. Additional figures and Tables.
Yusufzai, Samina, Hasnah Osman, Khan, Mohammad, Razik, Basma Abd, Ezzat, Mohammed, Suriyati Mohamad, Sulaiman, Othman, Jualang Gansau, Thaigarajan Parumasivam   +8 more
openaire   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Spillover and crossover effects of exposure to work‐related aggression and adversities: A dyadic diary study

Aggressive Behavior, Volume 49, Issue 1, Page 85-95, January 2023., 2023
Abstract The past two decades have produced extensive evidence on the manifold and severe outcomes for victims of aggression exposure in the workplace. However, due to the dominating individual‐centered approach, most findings miss a social network perspective.
Alexander Herrmann, Jürgen Glaser, Tobias Greitemeyer   +2 more
wiley   +1 more source

Investigating Constraint Relationship in Evolutionary Many-Constraint Optimization [PDF]

arXiv, 2020
This paper contributes to the treatment of extensive constraints in evolutionary many-constraint optimization through consideration of the relationships between pair-wise constraints. In a conflicting relationship, the functional value of one constraint increases as the value in another constraint decreases.
arxiv  

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Phytotherapy Research, 2018
Based on World Health Organization reports, resistance of bacteria to well‐known antibiotics is a major global health challenge now and in the future.
F. Farhadi, B. Khameneh, M. Iranshahi, Milad Iranshahy   +3 more
semanticscholar   +1 more source

Structure Activity Relationship of Dendrimer Microbicides with Dual Action Antiviral Activity [PDF]

, 2010
Topical microbicides, used by women to prevent the transmission of HIV and other sexually transmitted infections are urgently required. Dendrimers are highly branched nanoparticles being developed as microbicides.
A Adachi, A Hantson, Adam Johnson, B Etemad-Moghadam, BJ Boyd, BK Nanjwade, BP Roberts, BR Mathews, BT Galen, C Lackman-Smith, CC Huang, CD Rizzuto, CF Price, CJ Birch, CJ Lacey, CJ Springer, CS Dezzutti, D Binder, D Huskens, David Tyssen, DI Bernstein, DM Butler, E Gong, EE Freeman, F Gao, Gareth R. Lewis, Gilda Tachedjian, Guy Krippner, IA Scordi-Bello, J Balzarini, J Liu, J O'Loughlin, J Sterjovski, JA Levy, Jasminka Sterjovski, JE Cummins Jr, Jennifer La, Jeremy R. A. Paull, JF Salazar-Gonzalez, JM Brown, JP Moore, Katie Moore, L Gray, L Van Damme, LM Kaminskas, M Chisembele, M Moulard, M Witvrouw, Mark Zanin, Michael P. Giannis, MJ McElrath, MJ Wawer, MY Chen, N Bourne, Paul A. Ramsland, Paul R. Gorry, Peter Karellas, PG Spear, PJ Feldblum, PM Mesquita, PR Gorry, PS Fletcher, QA Karim, R Pauwels, R Wyatt, RA Cone, Richard Cone, RJ Shattock, S Harada, S Rusconi, S Skoler-Karpoff, S Sonza, S Sonza, S Weller, SA Karim, Scott A. Henderson, Secondo Sonza, SH Yap, SR Abner, Steve Wesselingh, TD McCarthy, TJ Ketas, Tom McCarthy, V Gajbhiye, W Tao, X Wei, YH Jiang, YJ Zhang, Zandrea Ambrose   +88 more
core   +3 more sources

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source