Results 81 to 90 of about 1,492,525 (254)
Structural insights and biological activities of flavonoids: Implications for novel applications
Food FrontiersFlavonoids are a major class of polyphenolic compounds that occur naturally in plants and are widely distributed in various dietary products. Flavonoids exhibit prominent physicochemical properties and biological activities, thereby garnering ...
Sheng Tang +7 more
doaj +1 more source
Relationship Between Structure And Antimicrobial Activity Of Zinc Oxide Nanoparticles: An Overview
International Journal of Nanomedicine, 2019 Bruna Lallo da Silva,1 Marina Paiva Abuçafy,1 Eloisa Berbel Manaia,1 João Augusto Oshiro Junior,1 Bruna Galdorfini Chiari-Andréo,1,2 Rosemeire CL R Pietro,1 Leila Aparecida Chiavacci1 1Department of Drugs and Medicines, School of ...
Lallo da Silva B +6 more
doaj
Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Synthesis and activity of novel indole derivatives as inhibitors of CD38
Acta Pharmaceutica Sinica B, 2013 CD38 is a multifunctional enzyme/receptor expressed in a variety of mammalian tissues, regulating a wide range of physiological functions. Beginning with the previously reported compound 1, an inhibitor of human CD38 NADase, we synthesized a series of ...
Dongying Wu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The Relationship between Physical Activity and Body Mass Index: Issues in Model Specification
, 2009 *Objective:* To investigate the best statistical models that describe the effect of physical activity on BMI. *Design:* Cross-sectional analyses of physical activity and BMI data.Subjects: 107 obese, overweight, and healthy college students ...
Gizachew Tiruneh, Gizachew Tiruneh
core +1 more source
Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics
MedComm – OncologyJanus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited therapeutic benefits due to their lack of selectivity.
Tian‐Hua Wei +18 more
doaj +1 more source
The Structure-Activity Relationship of the Antioxidant Peptides from Natural Proteins
Molecules, 2016 Peptides derived from dietary proteins, have been reported to display significant antioxidant activity, which may exert notably beneficial effects in promoting human health and in food processing.
Tang-Bin Zou +4 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
We have prepared a series of analogs of the complex marine macrolide (–)-zampanolide, which incorporate a dioxane-, oxathiane-, or oxathiane-dioxide ring in place of the natural tetrahydropyran moiety and we have determined their microtubule-binding ...
Simon, Glauser +9 more
core +1 more source