Results 81 to 90 of about 3,678,281 (266)

Bioinformatics, bacterial expression and enzyme activity analyses of dichloromethane dehalogenase from Methylobacterium rhodesianum H13

Biotechnology & Biotechnological Equipment, 2020
Dechlorination is the key step in biological degradation of dichloromethane (DCM), which is catalyzed by the enzyme DCM dehalogenase. In this study, the detailed structure and function of DCM dehalogenase in Methylobacterium rhodesianum H13 were ...
Jianguo Ni, Ying Liu, Chenjia Shen, Dongzhi Chen, Yueyong Xin, Qi Liu   +5 more
doaj   +1 more source

Structure-activity relationships on cynnamoyl derivatives as inhibitors of p300 Histone acetyltransferase [PDF]

, 2017
Human p300 is a polyhedric transcriptional coactivator, playing a crucial role by acetylating histones on specific lysine residues. A great deal of evidences shows that p300 is involved in several diseases as leukemia, tumors and viral infection.
Alberter, Arif, Artico, Azoulay, Balasubramanyam, Barreca, Brown, Chen, Choi, Costi, Costi, Dekker, Devipriya, Eckner, Farid, Gao, Getun, Ghizzoni, Granchi, Iyer, Iyer, Iyer, Kurdistani, Ligeret, Liu, Maddox, Mai, Maksimoska, Marcu, Noh, Osman, Ravindra, Robles, Sherman, Sherman, Sterner, Stimson, Thompson, Tintori, Toth, Tuccinardi, Valor, Vempati, Wang, Wong, Yasufumi, Zhao, Zheng, Zheng, Zhu   +49 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

What turns galaxies off? The different morphologies of star-forming and quiescent galaxies since z~2 from CANDELS [PDF]

, 2011
We use HST/WFC3 imaging from the CANDELS Multicycle Treasury Survey, in conjunction with the Sloan Digital Sky Survey, to explore the evolution of galactic structure for galaxies with stellar masses >3e10M_sun from z=2.2 to the present epoch, a time span
Abazajian, Aday R. Robaina, Anton Koekemoer, Arjen van der Wel, Avishai Dekel, Baugh, Bell, Bell, Bell, Bell, Bell, Benson, Bezanson, Blanton, Blanton, Brammer, Brammer, Brown, Bundy, Bundy, Cameron, Casey Papovich, Cassata, Cheung, Christina C. Williams, Christopher J. Conselice, Dale Kocevski, Daniel H. McIntosh, David C. Koo, Davis, Dekel, Donley, Drory, Duilia de Mello, Edmond Cheung, Elizabeth J. McGrath, Eric F. Bell, Faber, Fioc, Franx, Furusawa, Graham, Grogin, Győry, Gültekin, Hans-Walter Rix, Harry Ferguson, Hoffman, Hopkins, Hopkins, Häring, Häussler, Häußler, Ilbert, James S. Dunlop, Jennifer Lotz, Jessica Herrington, Jeyhan Kartaltepe, Johansson, Kannappan, Karim, Kartaltepe, Khochfar, Koekemoer, Kriek, Kriek, Kriek, Lee, Lupton, Magorrian, Martig, Mauro Giavalisco, McGrath, Moster, Naab, Noeske, Norman Grogin, Pannella, Papovich, Papovich, Papovich, Patel, Peng, Peng, Peng, Peng, Prochaska, Rix, Robaina, Ruhland, S. M. Faber, Salim, Salim, Schlegel, Scoville, Simard, Skrutskie, Somerville, Springel, Stijn Wuyts, Stockton, Strateva, Szomoru, Sérsic, Tal, Taylor, Taylor, Tremonti, Tremonti, van den Bergh, van der Wel, van der Wel, van der Wel, van der Wel, van Dokkum, van Dokkum, Wake, Wake, Weinmann, Whitaker, Whitaker, Williams, Williams, Wuyts, Wuyts, Wuyts, Wuyts, Wuyts, Yang, Yi, Zheng   +130 more
core   +5 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Metabolic profile and structure–activity relationship of resveratrol and its analogs in human bladder cancer cells

Cancer Management and Research, 2019
Yang Yang,1,2 Guangyuan Zhang,2 Chuangang Li,3 Sihan Wang,2 Manning Zhu,2 Jinan Wang,2 Hangtian Yue,2 Xiaodong Ma,2 Yuhong Zhen,2 Xiaohong Shu1,21College of Integrative Medicine, Dalian Medical University, Dalian 116044, People’s Republic of China;
Yang Y, Zhang G, Li C, Wang S, Zhu M, Wang J, Yue H, Ma X, Zhen Y, Shu X   +9 more
doaj  

Antifouling Activity of Simple Synthetic Diterpenoids against Larvae of the Barnacle Balanus albicostatus Pilsbry

Molecules, 2010
Five new pimarane diterpenoids 1-5 were synthesized using ent-8(14)-pimarene-15R,16-diol as starting material. The structures were elucidated by means of extensive NMR and MS analysis.
Dan-Qing Feng, Yi-Ming Lin, Jun-De Chen, Cui-Ling Sun, Rui-Zao Yi   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Docking and QSAR Studies of Camptothecin Derivatives as Inhibitor of DNA Topoisomerase-I [PDF]

, 2011
Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme Topoisomerase-I (Topo-I) and has shown remarkable anticancer activity in preliminary clinical trials. The major limitation is its low solubility and high adverse reaction.
Dharmendra K. Yadav, Feroz Khan, Santosh K. Srivastava   +2 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source