Results 101 to 110 of about 1,492,525 (254)

A Class of Promising Acaricidal Tetrahydroisoquinoline Derivatives: Synthesis, Biological Evaluation and Structure-Activity Relationships

Molecules, 2014
As part of our continuing research on isoquinoline acaricidal drugs, this paper reports the preparation of a series of the 2-aryl-1-cyano-1,2,3,4-tetrahydroisoquinolines with various substituents on the N-phenyl ring, their in vitro acaricidal activities
Rui Yang, Qiao Ruan, Bing-Yu Zhang, Zuo-Lue Zheng, Fang Miao, Le Zhou, Hui-Ling Geng   +6 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Exploring the relationship between gamma-band activity and maths anxiety [PDF]

, 2019
Previous research has outlined high anxiety in connection with gamma modulation, identifying that gamma-band activity (40–100 Hz) correlates with processing of threat perception, attention and anxiety.
Batashvili, Michael, Sheffield, David, Staples, Paul, Baker, Ian   +3 more
core   +1 more source

Volvariella polysaccharides: isolation, structural characterization and structure-activity relationship: a review

Journal of Future Foods
In recent years, Volvariella polysaccharides (VPs) have been confirmed with various of biological activities, which can be used as the main ingredients of functional foods.
Lin Guo, Jie Wang, Hui Liu, Huanjie Zhang, Fathy M.S.A. Mehaya, Changyang Ma   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Physical activity and depressive symptoms in adolescents: a prospective study [PDF]

, 2010
Background: The frequency of mental illness amongst adolescents and its potential long-term consequences make it an important topic to research in relation to risk and protective factors.
Viner Russell M, Stansfeld, SA, Stephen A Stansfeld, Kamaldeep Bhui, Viner, Russell M, Russell M Viner, Rothon, Catherine, Edwards Phil, Taylor, S, Edwards, P, Bhui, K, Bhui Kamaldeep, Taylor, Stephanie, Rothon Catherine, Stansfeld Stephen A, Viner, RM, Phil Edwards, Catherine Rothon, Bhui, Kamaldeep, Taylor Stephanie, Stansfeld, Stephen A, Edwards, Phil, Rothon, C, Stephanie Taylor   +23 more
core   +1 more source

First Total Syntheses and Antimicrobial Evaluation of Penicimonoterpene, a Marine-Derived Monoterpenoid, and Its Various Derivatives

Marine Drugs, 2014
The first total synthesis of marine-derived penicimonoterpene (±)-1 has been achieved in four steps from 6-methylhept-5-en-2-one using a Reformatsky reaction as the key step to construct the basic carbon skeleton.
Jian-Chun Zhao, Xiao-Ming Li, James B. Gloer, Bin-Gui Wang   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

3D-QSAR study and pharmacophore development of novel antidepressants affecting serotonine transporters and histamine H3 receptors [PDF]

, 2015
Depresija je najčešći mentalni poremećaj koji pogađa oko 350 miliona ljudi širom sveta. Selektivni inhibitori preuzimanja serotonina (SSRIs- Selective Serotonine Reuptake Inhibitors) su lekovi izbora u lečenju depresije.
Nikolić, Katarina, Agbaba, Danica, Đoković, Nemanja   +2 more
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