Results 111 to 120 of about 1,492,525 (254)
Growth Inhibition of Tanshinones on SPC-A-1 Cell Line and their Structure-activity Relationship
Chinese Journal of Lung Cancer, 2011 Background and objective Numerous studies have shown that Tanshinones have anti-tumor effects in vitro, but few studies were focusing on the anti-tumor activity of Tanshinones against one special cancer cell line.
Huayue SHI +5 more
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2016 Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori α-Carbonic ...
CT Supuran (15794282) +3 more
core
, 2006 A Three-Dimensional Quantitative Structure-activity Relationship (3D-QSAR) model that correlates the biological activities with the chemical structures of a series of Glucose-6-phosphatase inhibitors, exemplified by the 4,5,6,7-tetrahydrothienopyridines ...
Yang, SL, Yang, L, Wang, C
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Structure-activity relationship studies on aza analogues of illudins
, 2001 Illudin S and illudin M are extremely cytotoxic sesquiterpenes produced in cultures of basdiomycete Omphalotus illudins. Some of the analogues of illudins have been found to be quite effective at inhibiting tumor growth, while the others are not.
Ozkan, R, Tezer, N
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Py-Graph: An Easy-To-Use Interface for Building Graph-Based QSAR Models
, 2022 Graph Neural Networks (GNNs) have been proved to be effective for the prediction of molecules’ properties using the molecular graph. These models not only allow to obtain high classification and regression performances, but, with the help of ...
Roberto Capobianco +2 more
core
Research Progress of Natural Active Substances with Immunosuppressive Activity
MoleculesThe increasing prevalence of autoimmune diseases globally has prompted extensive research and the development of immunosuppressants. Currently, immunosuppressive drugs such as cyclosporine, rapamycin, and tacrolimus have been utilized in clinical ...
Fei Shao +7 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source