Results 41 to 50 of about 1,988,984 (222)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Spatial heterogeneity as the structure feature for structure–property relationship of metallic glasses

Nature Communications, 2018
Directly relating the mechanical properties of metallic glasses to their atomic structure remains a challenge. Here, the authors use high resolution microscopy to show many mechanical properties of metallic glasses depend on a single structural parameter,
Fan Zhu, Shuangxi Song, Kolan Madhav Reddy, Akihiko Hirata, Mingwei Chen   +4 more
doaj   +1 more source

Promoting the performance of Nb2O5 by doping transition metal oxide for catalytic degradation of monochlorobenzene and toluene

Journal of Materials Research and Technology, 2023
A string of niobium–based transition metal composite oxides (named as Nb2O5-MOx, M = Cr, V, Ti, Cu, Co, Fe, Mn and Ni, respectively) were synthesized, and their catalytic performances for the elimination of monochlorobenzene/toluene as typical VOCs were ...
Jiang Liu, Shufeng Zuo, Siyu Lin, Bofang Shan, Xiang Zhou, Junhu Zhao, Chenze Qi, Peng Yang   +7 more
doaj   +1 more source

Stochastic attractors for shell phenomenological models of turbulence [PDF]

, 2009
Recently, it has been proposed that the Navier-Stokes equations and a relevant linear advection model have the same long-time statistical properties, in particular, they have the same scaling exponents of their structure functions.
A. Debussche, A. Debussche, A. Pazy, C. Foias, D. Barbato, D.N. Cheban, E.B. Gledzer, Edriss S. Titi, F. Flandoli, F. Flandoli, F. Flandoli, Franco Flandoli, G. Gallavotti, G. Prato Da, H. Crauel, H. Crauel, H. Crauel, Hakima Bessaih, I. Arad, J. Hale, L. Angheluta, L. Arnold, L. Biferale, L.C. Berselli, M. Yamada, O.A. Ladyzhenskaya, P. Constantin, P. Constantin, P. Constantin, P. Constantin, P. Constantin, R. Benzi, R. Temam, T. Caraballo, U. Frisch, V.S. L’vov, Y. Cohen   +36 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

On the elastic microstructure of bulk metallic glasses

Materials & Design, 2023
Metallic glasses (MGs) are known to be structurally heterogeneous at the nanometer (nm) scale. In addition, elastic property mapping has indicated the presence of at least an order-of-magnitude larger length scales, of which the origin continues to ...
Birte Riechers, Catherine Ott, Saurabh Mohan Das, Christian H. Liebscher, Konrad Samwer, Peter M. Derlet, Robert Maaß   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source