Results 51 to 60 of about 13,270,820 (232)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Design and development of heterogeneous aluminum matrix hybrid composites for enhanced ductility

open access: yesJournal of Alloys and Metallurgical Systems
Traditional aluminum-based composite materials are limited in application due to the contradiction between strength and ductility. To address this, a dual matrix composite system based on Al-TiO2-H3BO3 was developed using ball milling, cold pressing, and
Tasratur Reaj Neha   +7 more
doaj   +1 more source

Design and structure–property relationship of benzothienoisoindigo in organic field effect transistors† [PDF]

open access: yesRSC Advances, 2015
A novel planar π-conjugated small molecule, benzothienoisoindigo (BTII), in which additional benzene rings are fused with the thieoisoindigo (TII) unit, has been designed and synthesized.
Tsukasa Hasegawa   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Cell structure-impact property relationship of polypropylene/thermoplastic elastomer blend foams

open access: yeseXPRESS Polymer Letters, 2019
The purpose of the present study was to investigate the effect of cellular structure on the impact strength of polypropylene/polyolefin elastomers blend foams produced by the continuous extrusion process.
A. Heidari, M. Fasihi
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

An explanation of capital structure of China's listed property firms

open access: yes, 2014
Purpose: The purpose of this paper is to investigate the determinants of the capital structure of listed property firms in China.Design/methodology/approach: The study is based on quantitative methods such as dynamic panel data models and a panel data ...
Song, Han-Suck,, Liang, J., Li, L. F.
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

open access: yesFEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui   +4 more
wiley   +1 more source

Establishing Flow Stress and Elongation Relationships as a Function of Microstructural Features of Ti6Al4V Alloy Processed using SLM

open access: yesDesigns, 2019
Selective laser melting (SLM) is an attractive technology for fabricating complex metal parts with reduced number of processing steps compared to traditional manufacturing technologies.
Javed Akram   +2 more
doaj   +1 more source

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