Results 221 to 230 of about 976,396 (264)

Structure-Activity Relationships in Coumermycins

1972
Publisher Summary This chapter focuses on the structure–activity relationships in coumermycins. The naturally occurring coumermycins are produced in fermentation broths of several species of Streptomyces . Degradative studies at Bristol–Banyu Research Institute established the structures of coumermycins A 1 and A 2 .
J C, Godfrey, K E, Price
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Statistical Analysis of Structure-Activity Relationships

Toxicological Sciences, 1983
The relationship between organic structure and biological activity (toxicity) is examined by statistically comparing concentration-response regression lines among structurally related compounds. Response data from acute toxicity tests are initially transformed to the logistic function while concentration data are transformed to the logarithm base 10 ...
K L, Daniels, J C, Goyert, R H, Strand, M P, Farrell   +3 more
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Exploiting Structure–Activity Relationships in Docking

Journal of Chemical Information and Modeling, 2008
From the perspective of 2D chemical descriptors, error in docking activity predictions is separated into noise and systematic components. This error framework explains how fitting docking scores to a 2D-QSAR equation often improves accuracy as well as its logical limits.
David C. Sullivan, Eric J. Martin
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Structure-Activity Relationships in Glucocorticoids

1979
Meaningful answers to the question of the relationship between glucocorticoid structure and activity have emerged. Structural change has predictable effects on susceptibility to the action of metabolizing enzymes, on receptor affinity, and on intrinsic activity. These effects are, in principle, amenable to mathematical modeling techniques.
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Structure-Activity Relationships

2019
In-depth analysis of the structure of the drug and its subsequent modification yield drugs with high affinity and increased receptor specificity with an improved pharmacokinetic profile. Modification of the parent molecule of catecholamines, called β-phenyl-ethyl-amine, provided orally active adrenergic bronchodilators, long-acting β2-adrenergic ...
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Structure-Activity Relationships

1971
Most fungicides available today were discovered empirically. The information from these studies can be used to integrate structural characteristics of a fungicide with its toxic action. The characteristics so identified portray, in part, the nature of fungitoxic action.
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Structure-Activity Relationships

1999
Estrogens and antiestrogens are understood to exert their hormonal action after binding to the estrogen receptor (ER), a member of the nuclear receptor superfamily. Until recently, the knowledge of the shape of the full-length ER and the structure of the hormone-binding domain has been rather vague, due to the lack of cristallographie data. Information
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Structure-activity relationships

Environmental Science & Technology, 1984
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American Cancer Society guideline for diet and physical activity for cancer prevention

Ca-A Cancer Journal for Clinicians, 2020
Colleen Spees, Ted Gansler, Alpa Patel   +2 more
exaly  

Structure-Activity Relationships in Chemoreception

Trends in Biochemical Sciences, 1976
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