Results 71 to 80 of about 5,517,395 (407)

Comparison of kinship‐identification methods for robust stock assessment using close‐kin mark–recapture data for Pacific bluefin tuna

Population Ecology, EarlyView.
In this study, we compared three methods for kinship identification using different algorithms in samples of wild Pacific bluefin tuna and generated genotyping data. The three methods resulted in different numbers of inferred kinship pairs for both generated and actual data. Particularly for the half‐sibling pairs, considerable number of false‐positive
Yohei Tsukahara, Reiichiro Nakamichi, Aiko Matsuura, Tetsuya Akita, Atushi Fujiwara, Nobuaki Suzuki   +5 more
wiley   +1 more source

Current Research on Antiepileptic Compounds

Molecules, 2015
Epilepsy affects about 1% of the world’s population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the ...
Cheng-Xi Wei, Ming Bian, Guo-Hua Gong
doaj   +1 more source

Pyrimidine: a review on anticancer activity with key emphasis on SAR

Future Journal of Pharmaceutical Sciences, 2021
Background Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents.
Aastha Mahapatra, Tanya Prasad, Tripti Sharma   +2 more
doaj   +1 more source

Investigating Constraint Relationship in Evolutionary Many-Constraint Optimization [PDF]

arXiv, 2020
This paper contributes to the treatment of extensive constraints in evolutionary many-constraint optimization through consideration of the relationships between pair-wise constraints. In a conflicting relationship, the functional value of one constraint increases as the value in another constraint decreases.
arxiv  

Structure Activity Relationship of Dendrimer Microbicides with Dual Action Antiviral Activity [PDF]

, 2010
Topical microbicides, used by women to prevent the transmission of HIV and other sexually transmitted infections are urgently required. Dendrimers are highly branched nanoparticles being developed as microbicides.
A Adachi, A Hantson, Adam Johnson, B Etemad-Moghadam, BJ Boyd, BK Nanjwade, BP Roberts, BR Mathews, BT Galen, C Lackman-Smith, CC Huang, CD Rizzuto, CF Price, CJ Birch, CJ Lacey, CJ Springer, CS Dezzutti, D Binder, D Huskens, David Tyssen, DI Bernstein, DM Butler, E Gong, EE Freeman, F Gao, Gareth R. Lewis, Gilda Tachedjian, Guy Krippner, IA Scordi-Bello, J Balzarini, J Liu, J O'Loughlin, J Sterjovski, JA Levy, Jasminka Sterjovski, JE Cummins Jr, Jennifer La, Jeremy R. A. Paull, JF Salazar-Gonzalez, JM Brown, JP Moore, Katie Moore, L Gray, L Van Damme, LM Kaminskas, M Chisembele, M Moulard, M Witvrouw, Mark Zanin, Michael P. Giannis, MJ McElrath, MJ Wawer, MY Chen, N Bourne, Paul A. Ramsland, Paul R. Gorry, Peter Karellas, PG Spear, PJ Feldblum, PM Mesquita, PR Gorry, PS Fletcher, QA Karim, R Pauwels, R Wyatt, RA Cone, Richard Cone, RJ Shattock, S Harada, S Rusconi, S Skoler-Karpoff, S Sonza, S Sonza, S Weller, SA Karim, Scott A. Henderson, Secondo Sonza, SH Yap, SR Abner, Steve Wesselingh, TD McCarthy, TJ Ketas, Tom McCarthy, V Gajbhiye, W Tao, X Wei, YH Jiang, YJ Zhang, Zandrea Ambrose   +88 more
core   +3 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Inflammation and disease are closely related. Inflammation can induce various diseases, and diseases can promote inflammatory response, and two possibly induces each other in a bidirectional loop.
Ming Bian, Qian-qian Ma, Yun Wu, Huan-huan Du, Gong Guo-hua   +4 more
doaj   +1 more source

Hyper-relationship Learning Network for Scene Graph Generation [PDF]

arXiv, 2022
Generating informative scene graphs from images requires integrating and reasoning from various graph components, i.e., objects and relationships. However, current scene graph generation (SGG) methods, including the unbiased SGG methods, still struggle to predict informative relationships due to the lack of 1) high-level inference such as transitive ...
arxiv  

Structure–activity relationships of antibacterial peptides

Microbial Biotechnology, 2023
AbstractAntimicrobial peptides play a crucial role in innate immunity, whose components are mainly peptide‐based molecules with antibacterial properties. Indeed, the exploration of the immune system over the past 40 years has revealed a number of natural peptides playing a pivotal role in the defence mechanisms of vertebrates and invertebrates ...
Maria Gessica Ciulla, Fabrizio Gelain
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source